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EPHA1 Antibody

  • 货号：
    CSB-PA002360
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using EphA1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P21709
  • 基因名：
    EPHA1
  • 别名：
    EPH antibody; EPH receptor A1 antibody; EPH tyrosine kinase 1 antibody; EPH tyrosine kinase antibody; Epha1 antibody; EPHA1_HUMAN antibody; Ephrin receptor Eph A1 antibody; Ephrin type A receptor 1 antibody; Ephrin type-A receptor 1 antibody; EPHT 1 antibody; EPHT antibody; EPHT1 antibody; Erythropoietin producing hepatoma amplified sequence antibody; Erythropoietin-producing hepatoma receptor antibody; Esk antibody; hEpha1 antibody; MGC163163 antibody; Oncogene EPH antibody; Soluble EPHA1 variant 1 antibody; Soluble EPHA1 variant 2 antibody; Tyrosine protein kinase receptor EPH antibody; Tyrosine-protein kinase receptor EPH antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human EphA1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
  • 基因功能参考文献：
    1. EphA1 expression is decreased in ovarian serous carcinoma compared with normal fallopian tube and benign ovarian serous cystadenoma. Decreased EphA1 expression was more often detected in high-grade tumors. PMID: 29393455
    2. Results show that EPHA1 expression is up-regulated in ovarian cancer (OC) cells and provide evidence that it may promote the aggression of some OC cells. PMID: 28739735
    3. EPHA1 suppresses spreading and adhesion of HRT18 colorectal cancer cells through deactivation of ERK and JNK signaling pathways. PMID: 26977017
    4. Data indicate that EphA1 protein may be a new marker for the prognosis of clear cell renal cell carcinoma. PMID: 26261568
    5. High expression of EphA1 was associated with metastasis and recurrence in Gastric Cancer. PMID: 25391265
    6. This study suggests EPHA1 (rs11771145) interferes with the pathological alteration of the hippocampus and the lateral occipitotemporal and inferior temporal gyri throughout the Alzheimer's disease process, leading to a lower risk of Alzheimer's disease. PMID: 25182741
    7. EphrinA1 plays an important role in the TNF-alpha-mediated adhesion of monocytes to endothelial cells. PMID: 25451169
    8. Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma. PMID: 25025847
    9. two states of the EphA1 transmembrane helix dimer PMID: 25286141
    10. Suggest EphA1 receptor may have roles in carcinogenesis and progression of prostate cancer. PMID: 24040450
    11. High Eph A1 expression is associated with choriocarcinoma invasion. PMID: 23429488
    12. Results show that EphA1 appears to be a differentiation marker for esophageal squamous cells, and its increased expression is positively associated with lymph node metastasis and advanced disease stage. PMID: 23030051
    13. EphrinA1 is released in three forms from cancer cells by matrix metalloproteases PMID: 22688511
    14. The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer. PMID: 21503576
    15. found independent evidence for association for Alzheimer's disease susceptibility loci at EPHA1, CD33 and CD2AP PMID: 21460840
    16. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. PMID: 21460841
    17. The EphA1 expression level is a potential prognostic marker in gastric carcinoma, and may provide a novel target of therapy for gastric carcinoma. PMID: 21042754
    18. Eph-A1 staining intensity was significantly associated with tumor size and tumor histopathological stage in pancreatic ductal adenocarcinoma PMID: 19949912
    19. Suppression of EphA1 expression in Huh-7 cells reduced their outgrowth when inoculated in the subcutaneous space in the flank of nude mice, presumably through angiogenesis inhibition since microvessel density was found to be inhibited. PMID: 20043122
    20. EphA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. PMID: 16862074
    21. I 12 acquired a higher affinity toward EphA2 with K(d) 18 nm and inhibited vascular endothelial growth factor-dependent angiogenic invasion in a Matrigel plug assay PMID: 18308734
    22. Results suggest that EphA1-receptor transmembrane domains contribute to the dimerization-mediated receptor activation. PMID: 18590698
    23. analysis of the spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1 PMID: 18728013
    24. In EphA1 null transgenic mice a possible role for EphA1 in tissue patterning and hormone-induced apoptotic processes is indicated. PMID: 18802966
    25. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. PMID: 18990944
    26. EphA1 may play different roles during the different stages of colorectal carcinoma progression. PMID: 19011600
    27. EphA1 regulates cell morphology and motility through the ILK-RhoA-ROCK pathway. PMID: 19118217
    28. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. PMID: 19277044

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 组织特异性：
    Overexpressed in several carcinomas.
  • 数据库链接：

    HGNC: 3385

    OMIM: 179610

    KEGG: hsa:2041

    STRING: 9606.ENSP00000275815

    UniGene: Hs.89839