Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. EMX2 Antibody

EMX2 Antibody

  • 货号：
    CSB-PA008048
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q04743
  • 基因名：
    EMX2
  • 别名：
    Empty spiracles homeobox 2 antibody; Empty spiracles homolog 2 (Drosophila) antibody; Empty spiracles homolog 2 antibody; Empty spiracles like protein 2 antibody; Empty spiracles-like protein 2 antibody; EMX 2 antibody; EMX2 antibody; EMX2_HUMAN antibody; Homeobox protein EMX 2 antibody; Homeobox protein EMX2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Emx2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
  • 基因功能参考文献：
    1. EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival. PMID: 28830374
    2. Emx2 is a novel promising tool for therapy of glioblastoma and prevention of its recurrences. PMID: 27191499
    3. EMX2 inhibits proliferation and tumorigenesis through inactivation of the Wnt/beta-catenin pathway in CRC cells. PMID: 27712600
    4. EMX2 expression was down-regulated in lung SCC tissue compared to matched adjacent normal tissue. EMX2 expression was associated with improved overall survival. Knockdown promoted chemo-resistance and cell migration. PMID: 26132438
    5. Although it is uncommon (0.19%), EMX2 is the first gene identified that if perturbed may cause isolated incomplete mullerian fusion. PMID: 25577462
    6. Deletions of EMX2 have been associated with a wide range of DSD. PMID: 24975717
    7. EMX2 expression is downregulated in advanced cases of malignant pleural mesothelioma and may serve as an important prognostic and predictive molecular biomarker of progression-free survival. PMID: 25023662
    8. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer PMID: 23370654
    9. EMX2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo. PMID: 23029345
    10. Study analyzed mutations of EMX2 gene in 45 prostate carcinomas, 51 non-small cell lung cancers, 43 gastric carcinomas, 44 colorectal carcinomas, and 43 breast carcinomas by polymerase chain reaction and single-strand conformation polymorphism assay. PMID: 21917011
    11. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma. PMID: 21726823
    12. Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1. PMID: 21651764
    13. promoter. Restoration of EMX2 expression in lung cancer cells lacking endogenous EMX2 expression suppressed cell proliferation and invasive phenotypes PMID: 20697358
    14. EMX2 gene has been reported in schezencephaly (cleft brain) including epilepsy in some patients. PMID: 12185771
    15. In these studies we identify and characterize the regulation of EMX2 by HOXA10. PMID: 12482956
    16. Endometrial EMX2 expression is aberrant in women with endometriosis and is mediated by altered HOXA10 expression. PMID: 15126568
    17. EMX2 levels in cortical progenitors of EMX2 transgenic mice disproportionately specify sizes and positions of primary cortical areas. PMID: 15294144
    18. It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis. PMID: 17563403
    19. provide results of EMX2 sequencing in 39 new schizencephaly patients, detecting no pathogenic mutations PMID: 18409201
    20. These data support recent reports that EMX2 but not PAX6 is more directly involved in arealization, highlighting that analysis of human development allows better spatio-temporal resolution than studies in rodents. PMID: 18973570

    显示更多

    收起更多

  • 相关疾病：
    Schizencephaly (SCHZC)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    EMX homeobox family
  • 组织特异性：
    Cerebral cortex.
  • 数据库链接：

    HGNC: 3341

    OMIM: 269160

    KEGG: hsa:2018

    STRING: 9606.ENSP00000358202

    UniGene: Hs.202095