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EMR3 Antibody

  • 货号：
    CSB-PA070039
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BY15
  • 基因名：
  • 别名：
    ADGRE3; EMR3; UNQ683/PRO1562; Adhesion G protein-coupled receptor E3; EGF-like module receptor 3; EGF-like module-containing mucin-like hormone receptor-like 3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human EMR3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.
  • 基因功能参考文献：
    1. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, impetus is provided to explore EMR-3 as a potential therapeutic target. PMID: 20827226
    2. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased EMR1&3. PMID: 20625511
    3. The expression of EGF-TM7 receptors on myeloid cells is differentially regulated. EMR3 is the first family member found mainly on granulocytes. PMID: 17108056
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.; [Isoform 3]: Secreted.
  • 蛋白家族：
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 组织特异性：
    Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages.
  • 数据库链接：

    HGNC: 23647

    OMIM: 606101

    KEGG: hsa:84658

    STRING: 9606.ENSP00000253673

    UniGene: Hs.658712