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EMP3 Antibody

  • 货号：
    CSB-PA007650LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of Hela cells using CSB-PA007650LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      All lanes: EMP3 antibody at 3µg/ml + Mouse heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 19 kDa
      Observed band size: 19, 31 kDa
  • 其他：

产品详情

  • 产品描述：

    The EMP3 polyclonal antibody was generated in rabbits using recombinant human EMP3 protein (25-65aa) as the immunogen and purified to a level greater than 95% using protein G affinity chromatography. This liquid-form antibody has been tested and proven reactive with human and mouse samples, making it suitable for use in a variety of experimental contexts.

    Additionally, this EMP3 polyclonal antibody has been tested in ELISA and WB and has demonstrated its efficacy in recognizing and binding to EMP3 protein. The EMP3 polyclonal antibody's function includes the ability to detect, evaluate, and quantify EMP3 protein levels in biological samples.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EMP3 Polyclonal antibody
  • Uniprot No.：
    P54852
  • 基因名：
    EMP3
  • 别名：
    EMP3; YMP; Epithelial membrane protein 3; EMP-3; Hematopoietic neural membrane protein 1; HNMP-1; Protein YMP
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Epithelial membrane protein 3 protein (25-65AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EMP3 Antibody (CSB-PA007650LA01HU)，的标记方式是Non-conjugated。对于EMP3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007650LB01HU EMP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA007650LC01HU EMP3 Antibody, FITC conjugated
    Biotin CSB-PA007650LD01HU EMP3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably involved in cell proliferation and cell-cell interactions.
  • 基因功能参考文献：
    1. This study identified and validated a three-gene (EMP3, GSX2 and EMILIN3) prognostic signature in Lower-Grade Gliomas. PMID: 29794476
    2. High EMP3 expression is associated with high grade glioma. PMID: 27527869
    3. epithelial membrane protein 3 is a downstream effector of TWIST1/2 in inducing epithelial-to-mesenchymal transition in gastric cancer. Epithelial membrane protein 3 upregulation might be associated with gastric cancer metastasis and is a potential indicator of unfavorable overall survival and progression-free survival in gastric cancer patients PMID: 28718375
    4. Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy. PMID: 27801851
    5. The study provided a new insight into EMP3, suggesting that EMP3 enhances malignancy of hepatocellular carcinoma cells PMID: 26472188
    6. EMP3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. PMID: 26398721
    7. The aim of this study was to investigate the EMP3 promoter hypermethylation status in a series of 229 astrocytic and oligodendroglial tumors and in 16 glioblastoma cell lines. PMID: 24083241
    8. Decreased expression of EMP3 by promoter methylation is associated by lung cancer PMID: 23920144
    9. LOH 19q determines the complete loss of EMP3 function, as the conserved allele is frequently hypermethylated, and this may represent the molecular basis of the higher risk of relapse in this subgroup of grade II oligodendroglioma patients. PMID: 22992787
    10. The promoter methylation and mRNA expressions of EMP3 and PCDH-gamma-A11 are closely related with the malignant development of glioma. PMID: 20388442
    11. EMP3 overexpression is associated with oligodendroglial tumors PMID: 17187361
    12. Oligodendroglial and astrocytic gliomas show EMP3 hypermethylation and aberrant expression. Primary and secondary glioblastomas have distinct genetic profiles and also differ in their epigenetic aberrations. PMID: 17610521
    13. Loss of EMP3 is associated with esophageal squamous cell carcinoma. PMID: 18823699
    14. Epithelial membrane protein 3 overexpression in breast carcinomas was significantly related to histological grade III , lymph node metastasis , and strong Her-2 expression. PMID: 19270820

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PMP-22/EMP/MP20 family
  • 数据库链接：

    HGNC: 3335

    OMIM: 602335

    KEGG: hsa:2014

    STRING: 9606.ENSP00000270221

    UniGene: Hs.9999