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EMP1 Antibody

  • 货号：
    CSB-PA007648LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007648LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA007648LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EMP1 Polyclonal antibody
  • Uniprot No.：
    P54849
  • 基因名：
    EMP1
  • 别名：
    EMP1; B4B; TMP; Epithelial membrane protein 1; EMP-1; CL-20; Protein B4B; Tumor-associated membrane protein
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Epithelial membrane protein 1 protein (22-66AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EMP1 Antibody (CSB-PA007648LA01HU)，的标记方式是Non-conjugated。对于EMP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007648LB01HU EMP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA007648LC01HU EMP1 Antibody, FITC conjugated
    Biotin CSB-PA007648LD01HU EMP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. The abnormal expression of EMP-1 may be associated with progression of laryngeal carcinoma (LC) and the gene may act as a prognostic marker for LC. PMID: 28779068
    2. The studies implicating GAS3 protein family (EMP1, EMP2, EMP3 and PMP22) in cancer pathogenesis as well as probe the structural similarities between the family members were highlighted. PMID: 27279240
    3. Therefore, EMP1 is a tumor suppressor in laryngeal carcinoma. Boosting EMP1 expression in laryngeal carcinoma initiates multiple anticancer phenotypes and thus presents a promising therapeutic strategy for laryngeal cancer. PMID: 27909719
    4. SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.EMP1 localises to tight junctions and is essential for their formation and function. PMID: 25394671
    5. Low EMP1 expression in colorectal cancer is associated with increased disease severity, suggesting that EMP1 may be a negative regulator of colorectal cancer PMID: 24744589
    6. Results demonstrated that EMP1 protein levels were significantly reduced in gastric carcinoma and were associated with tumor invasion, lymph node metastasis, clinical stage and cell differentiation. PMID: 24920167
    7. EMP1 as an independent predictor for poor outcome in precursor-B ALL (BCP-ALL) (P=0.004, hazard ratio: 2.36 (1.31-4.25). PMID: 24625531
    8. EMP-1 was significantly up-regulated in NSCLC patients. PMID: 23271282
    9. EMP1 expression decreased in prostate cancer and correlated significantly T stages, lymph node metastasis, clinic stage, and Gleason score PMID: 24338711
    10. EMP1 could be a biomarker for aberrant epithelial remodelling and metaplasia in chronic inflammatory upper airway mucosa PMID: 24033346
    11. EMP1 may play important roles as a negative regulator to nasopharyngeal cancer cell. PMID: 24292952
    12. EMP1 may play important roles as a negative regulator to breast cancer MCF-7 cell by regulating the expression of caspase 9 and VEGFC protein. PMID: 24402572
    13. Overexpression of EMP1 in spinal chondrocytes promotes cell proliferation and survival, alters cell morphology and cell cycle, reduces cell condensation, and inhibits cell hypertrophy. PMID: 21538935
    14. The EMP1 gene may be implicated in the pathophysiology of MDD in the Japanese population. PMID: 21146590
    15. Decreased expression of EMP1 was significantly correlated with clinical stage (p=0.002) and lymph node metastasis (p=0.044) of patients with oral squamous cell carcinoma and may be a tumor suppressor. PMID: 20980531
    16. EMP-1 gene has some relationship with carcinogenesis of esophagus. PMID: 12451984
    17. Overexpression of human EMP-1 gene can inhibit the proliferation of EC9706 cell with S phase arrested and G1 phase prolonged. EMP-1 may be one of regulators involved in cell signaling, cell communication and adhesion regulators. PMID: 12632483
    18. role of the adhesion molecule, EMP-1, as a biomarker of gefitinib clinical resistance, and further suggests a probable cross-talk between this molecule and the epidermal growth factor receptor signaling pathway PMID: 16087880
    19. We found expression of EMP-1 mRNA was higher in intractable epilepsy per the gene scanning, EMP-1 immunoreactivity was apparent in neurons of IE patients but not in the control group, and the expression of EMP-1 and EGFR occurred in the same neuron. PMID: 19288191

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PMP-22/EMP/MP20 family
  • 数据库链接：

    HGNC: 3333

    OMIM: 602333

    KEGG: hsa:2012

    STRING: 9606.ENSP00000256951

    UniGene: Hs.719042