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EML1 Antibody

  • 中文名称：
    EML1兔多克隆抗体
  • 货号：
    CSB-PA007642GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O00423
  • 基因名：
    EML1
  • 别名：
    echinoderm microtubule associated protein like 1 antibody; Echinoderm microtubule-associated protein-like 1 antibody; ELP79 antibody; EMAL1_HUMAN antibody; EMAP antibody; EMAP-1 antibody; EMAPL antibody; Eml1 antibody; FLJ45033 antibody; HuEMAP antibody; HuEMAP-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EML1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
  • 基因功能参考文献：
    1. a homozygous truncating variant in EML1 is a novel cause of congenital hydrocephalus. PMID: 28556411
    2. We show that the trimerization domain (TD) of EML1 is necessary and sufficient for self-association. The TD is also essential for MT binding; however, this property requires an adjacent basic region. PMID: 25740311
    3. We found EML1 to be mutated in ribbon-like heterotopia in humans PMID: 24859200
    4. determined a 2.6-A crystal structure of the representative approximately 70-kDa core of EML1, revealing an intimately associated pair of beta-propellers, which we term a TAPE (tandem atypical propeller in EMLs) domain PMID: 24706829
  • 相关疾病：
    Band heterotopia (BH)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    WD repeat EMAP family
  • 组织特异性：
    Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 3330

    OMIM: 600348

    KEGG: hsa:2009

    STRING: 9606.ENSP00000334314

    UniGene: Hs.12451