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ELP2 Antibody

  • 货号：
    CSB-PA740224LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA740224LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA740224LA01HU diluted at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA740224LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ELP2 Polyclonal antibody
  • Uniprot No.：
    Q6IA86
  • 基因名：
    ELP2
  • 别名：
    AU023723 antibody; Elongation protein 2 homolog (S. cerevisiae) antibody; Elongator acetyltransferase complex subunit 2 antibody; Elongator complex protein 2 antibody; elongator protein 2 antibody; ELP2 antibody; ELP2_HUMAN antibody; Epl2 antibody; FLJ10879 antibody; SHINC 2 antibody; SHINC-2 antibody; SHINC2 antibody; signal transducer and activator of transcription 3 interacting protein 1 antibody; signal transducer and activator of transcription interacting protein 1 antibody; STAT3 interacting protein 1 antibody; Stat3 interacting protein antibody; STAT3-interacting protein 1 antibody; STATIP 1 antibody; STATIP1 antibody; STATIP1 protein antibody; StIP antibody; StIP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Elongator complex protein 2 protein (323-457AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ELP2 Antibody (CSB-PA740224LA01HU)，的标记方式是Non-conjugated。对于ELP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA740224LB01HU ELP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA740224LC01HU ELP2 Antibody, FITC conjugated
    Biotin CSB-PA740224LD01HU ELP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
  • 基因功能参考文献：
    1. ELP2 mutation is implicated in severe intellectual disability, spastic diplegia, and self-injurious behavior described in two brothers. PMID: 25847581
    2. Studied the possible relationship between STATIP1, STAT3 and CML resistance. PMID: 25417721
    3. Elp2 and STAT-3 mediate, at least in part, the stimulation of Hsp70 expression by 4PBA. PMID: 22069317
  • 相关疾病：
    Mental retardation, autosomal recessive 58 (MRT58)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    WD repeat ELP2 family
  • 数据库链接：

    HGNC: 18248

    OMIM: 616054

    KEGG: hsa:55250

    UniGene: Hs.606040