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ELMO2 Antibody

  • 货号：
    CSB-PA836237LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA836237LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA836237LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse heart tissue
      All lanes: ELMO2 antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 83, 73 kDa
      Observed band size: 83 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ELMO2 Polyclonal antibody
  • Uniprot No.：
    Q96JJ3
  • 基因名：
    ELMO2
  • 别名：
    CED 12 antibody; Ced 12 homolog 2 antibody; CED 12 homolog A antibody; CED 12A antibody; CED-12 antibody; ced-12 homolog 2 antibody; CED12 antibody; CED12 homolog A antibody; CED12; C. elegans; homolog of; 2 antibody; CED12A antibody; ELMO 2 antibody; ELMO-2 antibody; ELMO2 antibody; ELMO2_HUMAN antibody; Engulfment and cell motility 2 (ced 12 homolog; C. elegans) antibody; Engulfment and cell motility 2 antibody; Engulfment and cell motility gene 2 antibody; Engulfment and cell motility protein 2 antibody; FLJ11656 antibody; hCED 12A antibody; hCED-12A antibody; hCED12A antibody; KIAA1834 antibody; OTTHUMP00000031762 antibody; PH domain protein CED12A antibody; Protein ced 12 homolog A antibody; Protein ced-12 homolog A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Engulfment and cell motility protein 2 protein (304-371AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ELMO2 Antibody (CSB-PA836237LA01HU)，的标记方式是Non-conjugated。对于ELMO2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836237LB01HU ELMO2 Antibody, HRP conjugated ELISA
    FITC CSB-PA836237LC01HU ELMO2 Antibody, FITC conjugated
    Biotin CSB-PA836237LD01HU ELMO2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
  • 基因功能参考文献：
    1. These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells. PMID: 27539661
    2. studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization. PMID: 27226625
    3. findings highlight the necessity of ELMO2 for maintaining vascular integrity, specifically in intramembranous bones; loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling PMID: 27476657
    4. Axl has a role in phosphorylating the Elmo scaffold proteins to promote Rac activation and cell invasion PMID: 25332238
    5. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability PMID: 23184944
    6. Through its association with ELMO2, ILK plays key roles in the regulation of Rho GTPases and cross-talk pathways between adhesion and growth factor receptors. PMID: 22568984

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  • 相关疾病：
    Vascular malformation, primary intraosseous (VMOS)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol. Membrane.
  • 组织特异性：
    Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
  • 数据库链接：

    HGNC: 17233

    OMIM: 606421

    KEGG: hsa:63916

    STRING: 9606.ENSP00000290246

    UniGene: Hs.210469