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ELF2 Antibody

  • 货号：
    CSB-PA618015DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ELF2 antibody at 2.27μg/ml
      Lane 1: HL60 whole cell lysate
      Lane 2: A549 whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Lane 4: Jurkat whole cell lysate
      Lane 5: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 64, 63, 57, 58, 55 kDa
      Observed band size: 64, 50 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA618015DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA618015DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ELF2 Polyclonal antibody
  • Uniprot No.：
    Q15723
  • 基因名：
    ELF2
  • 别名：
    ELF2 antibody; NERFETS-related transcription factor Elf-2 antibody; E74-like factor 2 antibody; New ETS-related factor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ETS-related transcription factor Elf-2 protein (1-140AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; Isoform 2 may function in repression of RUNX1-mediated transactivation.
  • 基因功能参考文献：
    1. Mutations in eIF2B genes cause vanishing white matter disease due to translation defects. PMID: 29632131
    2. Our findings collectively support a potential role of triiodothyronine and its receptor in tumor growth inhibition through regulation of ELF2 PMID: 26968954
    3. PCAT7 contributed to the progression of nasopharyngeal carcinoma through regulating miR-134-5p/ELF2 signaling pathway. PMID: 28728844
    4. angiopoietin-1 regulates expression of NERF2 and its own receptor in hypoxic cells. PMID: 11967990
    5. NERF/ELF-2 physically interacts with AML1 and mediates opposing effects on AML1-mediated transcription of the B cell-specific blk gene PMID: 14970218
    6. These findings indicate that ELF2/NERF promotes VCP transcription and that ELF2/NERF-VCP pathway might be important for cell survival and proliferation under cytokine stress. PMID: 17368566
    7. ELF2 transactivates VCP promoter through binding to two motifs, with a predominant contribution of the upstream one. PMID: 18544453
    8. Affinity of the CAL PDZ domain for the cystic fibrosis transmembrane conductance regulator (CFTR) C-terminus is much weaker than that of the NHERF1/NHERF2 domains, enabling wild-type CFTR to avoid premature entrapment in the lysosomal pathway. PMID: 18754678

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung,
  • 数据库链接：

    HGNC: 3317

    KEGG: hsa:1998

    STRING: 9606.ENSP00000265495

    UniGene: Hs.634040