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EIF4H Antibody

  • 货号：
    CSB-PA007571GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q15056
  • 基因名：
  • 别名：
    AU018978 antibody; D5Ertd355e antibody; E430026L18Rik antibody; Ef4h antibody; eIF 4H antibody; eIF-4H antibody; EIF4H antibody; Eukaryotic translation initiation factor 4H antibody; IF4H_HUMAN antibody; KIAA0038 antibody; WBSCR1 antibody; Williams Beuren syndrome chromosomal region 1 protein homolog antibody; Williams Beuren syndrome chromosome region 1 antibody; Williams-Beuren syndrome chromosomal region 1 protein antibody; Williams-Beuren syndrome chromosome region 1 antibody; WSCR1 antibody
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EIF4H
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
  • 基因功能参考文献：
    1. The results from these procedures revealed eIF4H to be one of the targets of miR-519d. Downregulated eIF4H was analogous to the overexpressed miR-519d obtained from miR-519d agomir and si-eIF4H transfection. In summary, it can be concluded that miR-519d targets eIF4H in lung adenocarcinoma to inhibit cell proliferation and invasion PMID: 28351305
    2. Results demonstrate that eukaryotic translation initiation factor 4H (eIF4H) plays a crucial role in translational control. PMID: 26498689
    3. Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-kappaB. PMID: 23776612
    4. Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR. PMID: 21427765
    5. results suggest that eIF4H isoform 1 plays an important role in carcinogenesis through the activation of oncogenic signaling and could be a promising molecular target for cancer therapy PMID: 20473909
    6. data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES PMID: 15078951
    7. eIF4H binding is required for herpes simplex virus virion host shutoff-induced degradation of many mRNAs, perhaps by targeting Vhs to mRNAs and to preferred sites within mRNAs. PMID: 18448541
    8. The interaction of eIF4AI with two accessory factors, eIF4B and eIF4H, was studied. PMID: 18719248
    9. Study reports the topology of the eIF4A/4G/4H helicase complex, which is built from multiple experimentally observed domain-domain contacts. PMID: 19203580
    10. Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. PMID: 19369421

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  • 相关疾病：
    EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 组织特异性：
    The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.
  • 数据库链接：

    HGNC: 12741

    OMIM: 603431

    KEGG: hsa:7458

    STRING: 9606.ENSP00000265753

    UniGene: Hs.520943