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EIF4G2 Antibody

  • 货号：
    CSB-PA002071
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using DAP-5 Polyclonal Antibody
    • Western Blot analysis of HepG2 cells using DAP-5 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P78344
  • 基因名：
    EIF4G2
  • 别名：
    DAP-5 antibody; DAP5 antibody; Death associated protein 5 antibody; Death-associated protein 5 antibody; eIF-4-gamma 2 antibody; eIF-4G 2 antibody; eIF4G 2 antibody; EIF4G2 antibody; Eukaryotic translation initiation factor 4 gamma 2 antibody; IF4G2_HUMAN antibody; Nat1 antibody; Novel APOBEC-1 target 1 antibody; p97 antibody; Translation repressor NAT1 antibody; Translation repressor NAT1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human DAP-5.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
  • 基因功能参考文献：
    1. The percentage at the S-stage was decreased in the miR-379 mimics and EIF4G2 shRNA groups. PMID: 28381518
    2. DAP5 knockdown from human ESCs (hESCs) resulted in persistence of pluripotent gene expression, delayed induction of differentiation-associated genes in different cell lineages, and defective embryoid body formation PMID: 27664238
    3. Data show that microRNA miR-379 potentiated lung cancer (LCa) chemosensitivity via modulation of cisplatin (CDDP)-induced apoptosis by directly targeting the eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) 3' UTR. PMID: 28117895
    4. These results indicate that miR-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR-139 in chondrocytes may be related to its regulation on EIF4G2 and IGF1R. PMID: 27105918
    5. The Coxsackievirus B3 protease 2A-mediated cleavage of DAP5 results in the production of two truncates that exert differential effects on protein translation of the IRES-containing genes, leading to enhanced host cell death. PMID: 26586572
    6. Knockdown of EIF4G2 recapitulated the effects of mir-139, whereas restoring EIF4G2 expression rescued the mir-139 phenotype. elevated miR-139-5p expression is associated with a favorable outcome in acute myeloid leukemia. PMID: 26165837
    7. findings provide the first mechanistic insights into the function of DAP5 as a selective regulator of cap-independent translation PMID: 25779044
    8. Our results provide evidence that the tumor suppressor effect of miR-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII is a key effector of this anti-tumor activity. PMID: 24497838
    9. DAP5, a translation initiation factor shown to positively regulate the translation of various internal ribosome entry sites containing mRNAs, promotes internal ribosome entry site-driven translation of p53 mRNA. PMID: 23318444
    10. DAP5/p97 and DAP5/p86 enhanced the translation of the anti-apoptotic protein Bcl-2 and inhibited cisplatin-induced apoptosis PMID: 22555068
    11. Multiple isoforms of eIF4GII arise from multiple promoters & alternative splicing events. A non-canonical CUG initiation codon extends the eIF4GII N-terminus. The eIF4GII N-terminus plays an alternative role in initiation factor assembly. PMID: 22909319
    12. crystal structure of C-terminal region (residues 540-897) of p97/EIF4G2 (at 2.0 Angstrom resolution): sequence/structure homology with EIF4G1 PMID: 20544972
    13. crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5 is presented. PMID: 20057060
    14. Includes the functional analysis of a similar protein in yeast. PMID: 11331597
    15. The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins PMID: 11943866
    16. endogenous eIF4GII was phosphorylated by Ca(2+)/calmodulin-dependent protein kinase I PMID: 14507913
    17. Cleavage of eIF4GII is induced in cells and in cell extracts by the FMDV leader protease (L(pro)) alone PMID: 15016848
    18. EIF4G2 transcripts exhibited three different expression patterns, downregulation was found in about 50% of the cases analyzed and EIF4G2 gene transcription was associated with invasive tumors. PMID: 16410684
    19. p97 is functionally different from the closely related C-terminal two-thirds of eIF4GI and it can positively promote protein synthesis and cell proliferation. PMID: 16932749
    20. These data indicate that full-length p97 is a translational activator with essential role(s) in unstressed cells, suggesting a reassessment of current models of p97 function. PMID: 17237356
    21. Data show that DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis. PMID: 18450493
    22. role and regulation of death-associated protein-5 (DAP5/p97/NAT1), a novel inhibitor of translational initiation, in acute promyelocytic leukemia cell differentiation and apoptosis PMID: 18491231
    23. Results report the crystal structure of the C-terminal region of DAP5/p97 extending between amino acids 730 and 897. PMID: 18722383
    24. Exclusive use of a GUG translation initiation codon is conserved in human, chicken, Xenopus, and zebrafish. PMID: 15718103
    25. translation starts exclusively at a non-AUG translation initiation codon (GUG). PMID: 9049310

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  • 蛋白家族：
    Eukaryotic initiation factor 4G family
  • 组织特异性：
    Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney.
  • 数据库链接：

    HGNC: 3297

    OMIM: 602325

    KEGG: hsa:1982

    STRING: 9606.ENSP00000340281

    UniGene: Hs.183684