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EIF4ENIF1 Antibody

  • 中文名称：
    EIF4ENIF1兔多克隆抗体
  • 货号：
    CSB-PA873633LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate, A549 whole cell lysate, Mouse brain tissue
      All lanes: EIF4ENIF1 antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 109, 89 kDa
      Observed band size: 130 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA873633LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA873633LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EIF4ENIF1 Polyclonal antibody
  • Uniprot No.：
    Q9NRA8
  • 基因名：
    EIF4ENIF1
  • 别名：
    2610509L04Rik antibody; 4E T antibody; 4E-T antibody; 4ET antibody; 4ET_HUMAN antibody; A930019J01Rik antibody; AA410001 antibody; AU021239 antibody; Clast 4 antibody; Clast4 antibody; D11Ertd166e antibody; eIF4E transporter antibody; Eif4enif1 antibody; Eukaryotic translation initiation factor 4E nuclear import factor 1 antibody; Eukaryotic translation initiation factor 4E transporter antibody; FLJ21601 antibody; FLJ26551 antibody; OTTMUSP00000000698 antibody; OTTMUSP00000005193 antibody; OTTMUSP00000005194 antibody; OTTMUSP00000036075 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Eukaryotic translation initiation factor 4E transporter protein (340-630AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EIF4ENIF1 Antibody (CSB-PA873633LA01HU)，的标记方式是Non-conjugated。对于EIF4ENIF1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873633LB01HU EIF4ENIF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA873633LC01HU EIF4ENIF1 Antibody, FITC conjugated
    Biotin CSB-PA873633LD01HU EIF4ENIF1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression. Required for the formation of P-bodies. Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism.
  • 基因功能参考文献：
    1. we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. PMID: 27342281
    2. our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap PMID: 26027925
    3. neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. PMID: 25456498
    4. that while both eIF4E1 and eIF4E2 bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E:4E-T interactions PMID: 23991149
    5. This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E, nor P-body components. PMID: 24335285
    6. Data demonstrate that EIF4ENIF1 is associated with dominantly inherited primary ovarian insufficiency. PMID: 23902945
    7. The c-Jun N-terminal kinase (JNK) is targeted to processing bodies in response to oxidative stress and promotes the phosphorylation of 4E-T. PMID: 22966201
    8. human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation PMID: 15840819
    9. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay is described. PMID: 16157702
    10. Overexpression of eIF4E-T triggers the movement of eIF4E into the processing bodies. PMID: 18343217
    11. Hsp90 probably contributes to the correct localization of eIF4E and 4E-T to stress granules and also to the interaction between eIF4E and eIF4G, both of which may be needed for eIF4E to acquire the physiological functionality PMID: 19850929

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  • 亚细胞定位：
    Cytoplasm, P-body. Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 16687

    OMIM: 607445

    KEGG: hsa:56478

    STRING: 9606.ENSP00000328103

    UniGene: Hs.517559