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EIF4EBP3 Antibody

  • 货号：
    CSB-PA007565HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA007565HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA007565HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EIF4EBP3 Polyclonal antibody
  • Uniprot No.：
    O60516
  • 基因名：
    EIF4EBP3
  • 别名：
    EIF4EBP3Eukaryotic translation initiation factor 4E-binding protein 3 antibody; 4E-BP3 antibody; eIF4E-binding protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EIF4EBP3 Antibody (CSB-PA007565HA01HU)，的标记方式是Non-conjugated。对于EIF4EBP3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007565HB01HU EIF4EBP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA007565HC01HU EIF4EBP3 Antibody, FITC conjugated
    Biotin CSB-PA007565HD01HU EIF4EBP3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
  • 基因功能参考文献：
    1. Role of the eIF4EBP3 gene in miR-22-3p-mediated cervical squamous carcinoma cell growth PMID: 29333098
    2. The data reveal that 4E-BP3 expression is controlled by the transcription factor TFE3 through a cis-regulatory element in the EIF4EBP3 gene promoter. PMID: 27319316
    3. 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2 PMID: 22684010
    4. potential prognostic factor for survival in patients with lung adenocarcinoma PMID: 20621385
    5. 4E-BP3 is associated with eIF4E in the cell nucleus and cytoplasm PMID: 12482586
    6. PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin PMID: 14507920
    7. there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK PMID: 14557257

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  • 蛋白家族：
    EIF4E-binding protein family
  • 组织特异性：
    Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.
  • 数据库链接：

    HGNC: 3290

    OMIM: 603483

    KEGG: hsa:8637

    STRING: 9606.ENSP00000308472

    UniGene: Hs.594084