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EIF4E3 Antibody

  • 货号：
    CSB-PA009234
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using eIF4E3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8N5X7
  • 基因名：
    EIF4E3
  • 别名：
    EIF4E3Eukaryotic translation initiation factor 4E type 3 antibody; eIF-4E type 3 antibody; eIF-4E3 antibody; eIF4E type 3 antibody; eIF4E-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human eIF4E3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.
  • 基因功能参考文献：
    1. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts. PMID: 28942592
    2. Following heat shock, eIF4E2 is found in both processing bodies and stress granules, whereas eIF4E3_A relocates only to stress granules. PMID: 27578149
    3. MNK1 and MNK2 inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression in diffuse large B-cell lymphoma. PMID: 25403230
    4. eIF4E3 impedes oncogenic transformation and its expression is lost in some cancers. PMID: 23587918
  • 蛋白家族：
    Eukaryotic initiation factor 4E family
  • 数据库链接：

    HGNC: 31837

    OMIM: 609896

    KEGG: hsa:317649

    STRING: 9606.ENSP00000393324

    UniGene: Hs.581355