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EIF3L Antibody

  • 货号：
    CSB-PA002298
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using eIF3L Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y262
  • 基因名：
    EIF3L
  • 别名：
    eIEF associated protein HSPC021 antibody; EIF3EIP antibody; eif3l antibody; EIF3L_HUMAN antibody; EIF3S11 antibody; EIF3S6IP antibody; Eukaryotic translation initiation factor 3 subunit 6 interacting antibody; Eukaryotic translation initiation factor 3 subunit 6-interacting protein antibody; Eukaryotic translation initiation factor 3 subunit E-interacting protein antibody; Eukaryotic translation initiation factor 3 subunit L antibody; eukaryotic translation initiation factor 3; subunit E interacting antibody; HSPC021 antibody; HSPC025 antibody; MSTP005 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human eIF3L.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
  • 基因功能参考文献：
    1. These results indicate an interaction of human eIF3L with yellow fever virus NS5 and that eIF3L overexpression facilitates translation, which has potential implications for virus replication. PMID: 23800076
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    EIF-3 subunit L family
  • 数据库链接：

    HGNC: 18138

    KEGG: hsa:51386

    STRING: 9606.ENSP00000416892

    UniGene: Hs.446852