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EIF3I Antibody

  • 货号：
    CSB-PA03105A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat brain tissue
      All lanes: EIF3I antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 37 kDa
      Observed band size: 37 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA03105A0Rb at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EIF3I Polyclonal antibody
  • Uniprot No.：
    Q13347
  • 基因名：
    EIF3I
  • 别名：
    eIF-3-beta antibody; eIF3 beta antibody; eIF3 p36 antibody; eIF3-beta antibody; eIF3-p36 antibody; eIF3i antibody; EIF3I_HUMAN antibody; EIF3S2 antibody; EIF3S2; formerly antibody; Eukaryotic translation initiation factor 3 subunit 2 antibody; Eukaryotic translation initiation factor 3 subunit 2 beta antibody; Eukaryotic translation initiation factor 3 subunit I antibody; eukaryotic translation initiation factor 3; subunit 2 (beta; 36kD antibody; eukaryotic translation initiation factor 3; subunit 2 beta; 36kDa antibody; eukaryotic translation initiation factor 3; subunit 2; formerly antibody; eukaryotic translation initiation factor 3; subunit I antibody; Predicted protein of HQ2242 antibody; PRO2242 antibody; TGF beta receptor interacting protein 1 antibody; TGF-beta receptor-interacting protein 1 antibody; TGFbeta receptor interacting protein 1 antibody; TGFbeta receptor-interacting protein 1 antibody; TRIP 1 antibody; TRIP-1 antibody; TRIP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Eukaryotic translation initiation factor 3 subunit I protein (1-323AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EIF3I Antibody (CSB-PA03105A0Rb)，的标记方式是Non-conjugated。对于EIF3I Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA03105B0Rb EIF3I Antibody, HRP conjugated ELISA
    FITC CSB-PA03105C0Rb EIF3I Antibody, FITC conjugated
    Biotin CSB-PA03105D0Rb EIF3I Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:10000
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
  • 基因功能参考文献：
    1. EIF3i may affect vesicular stomatitis virus (VSV) growth by regulating the host antiviral response in HeLa cells. PMID: 29173589
    2. High eIF3i expression is associated with melanoma. PMID: 28193911
    3. Clusterin is an independent predictive factor for prognosis of hepatocellular carcinoma and it facilitates metastasis through EIF3I/Akt/MMP13 signaling. PMID: 25609201
    4. eIF3i is a proto-oncogene that drives colon oncogenesis by translationally upregulating COX-2 and activating the beta-catenin signaling pathway PMID: 24056964
    5. findings report that short hairpin RNA mediated depletion of TRIP-1 gene transcripts in A549 cells promotes epithelial-mesenchymal transition (EMT); knockdown of TRIP-1 dramatically increased A549 responsiveness to TGF-beta1 induction of EMT PMID: 21378021
    6. eIF3i overexpression fosters the integration of growth signals by mTOR into the mRNA translation process, promoting protein synthesis and tumor growth. PMID: 16929481
    7. Subunit b of the eIF3 complex directly binds to HCV IRES domain III via its N-terminal-RRM. PMID: 19059401
    8. TGF-beta receptor interacting protein 1 (TRIP-1), which we show inhibits fibroblast collagen contraction, is higher in fetal than adult fibroblasts PMID: 19329541

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    EIF-3 subunit I family
  • 数据库链接：

    HGNC: 3272

    OMIM: 603911

    KEGG: hsa:8668

    STRING: 9606.ENSP00000362688

    UniGene: Hs.530096