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EIF3D Antibody

  • 货号：
    CSB-PA070116
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O15371
  • 基因名：
    EIF3D
  • 别名：
    eIF 3 zeta antibody; eIF-3-zeta antibody; eIF3 p66 antibody; eIF3 zeta antibody; eIF3d antibody; EIF3D_HUMAN antibody; eIF3p66 antibody; EIF3S7 antibody; Eukaryotic translation initiation factor 3 subunit 7 antibody; Eukaryotic translation initiation factor 3 subunit 7 zeta 66/67kDa antibody; Eukaryotic translation initiation factor 3 subunit D antibody; MGC126526 antibody; MGC17258 antibody; OTTHUMP00000197900 antibody; OTTHUMP00000197901 antibody; Translation initiation factor eIF3 p66 subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human eIF3ζ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
  • 基因功能参考文献：
    1. results indicate that eIF3D plays a key role in the proliferation of AML cells, and suggest that eIF3D silencing might be a potential therapeutic strategy for leukemia. PMID: 28801778
    2. eIF3d promotes gallbladder cancer (GBC) progression mainly via eIF3d-GRK2-AKT axis and it may be used as a prognostic factor. The therapeutic targeting of eIF3d-GRK2 axis may be a potential treatment approach for GBC. PMID: 28594409
    3. A transcript-specific eIF3 complex mediates global translational control of energy metabolism. PMID: 27477275
    4. Results provide evidences that EIF3D may function as a potential proto-oncogene that participates in the occurrence and progression of renal cell carcinoma. PMID: 27035563
    5. Knockdown of eIF3D inhibited breast cancer cell proliferation and invasion. PMID: 26617750
    6. eIF3d makes specific contacts with the RNA cap, as exemplified by cap analogue competition, and these interactions are essential for assembly of translation initiation complexes on eIF3-specialized mRNAs such as the cell proliferation regulator c-Jun PMID: 27462815
    7. the critical involvement of EIF3D in the survival and progression of melanoma cells PMID: 25322666
    8. EIF3D plays an important role in modulating glioma cell growth and migration. PMID: 25682860
    9. Findings suggest that eukaryotic translation initiation factor 3 subunit D (eIF3D) might play an important role in colon cancer progression. PMID: 25370813

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  • 相关疾病：
    Defects in EIF3D are associated with some cancers, such as prostate, breast and colon cancers. Disease susceptibility may be associated with variations affecting the gene represented in this entry. Down-regulation inhibits proliferation of cancers (PubMed:25370813, PubMed:25322666, PubMed:25682860, PubMed:26617750, PubMed:26008152, PubMed:26036682, PubMed:27035563).
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    EIF-3 subunit D family
  • 数据库链接：

    HGNC: 3278

    OMIM: 603915

    KEGG: hsa:8664

    STRING: 9606.ENSP00000216190

    UniGene: Hs.55682