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EIF2S2 (Ab-67) Antibody

  • 货号：
    CSB-PA566738
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells, using eIF2B (Ab-67) antibody.
    • Western blot analysis of extracts from JK cells (Lane 2), using eIF2B (Ab-67) antiobdy. The lane on the left is treated with systhesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EIF2S2 Polyclonal antibody
  • Uniprot No.：
    P20042
  • 基因名：
    EIF2S2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from N-terminal of Human eIF2B.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
  • 基因功能参考文献：
    1. Data suggest that eukaryotic translation initiation factor 2 subunit beta (eIF2beta) is a therapeutic target for lung cancer. PMID: 29624814
    2. This study provides mechanistic insight into the role of eIF5-carboxyl terminal domain's dynamic interplay with eIF1 and eIF2beta PMID: 22813744
    3. These findings suggest that alpha and beta subunits of eIF2 interact with each other and the beta-subunit plays a critical role both in the regulation and function of eIF2. PMID: 18639529
  • 蛋白家族：
    EIF-2-beta/eIF-5 family
  • 数据库链接：

    HGNC: 3266

    OMIM: 603908

    KEGG: hsa:8894

    STRING: 9606.ENSP00000364119

    UniGene: Hs.429180