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EIF2B3 Antibody

  • 货号：
    CSB-PA002287
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using eIF2Bγ Polyclonal Antibody
    • Western Blot analysis of K562 cells using eIF2Bγ Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9NR50
  • 基因名：
    EIF2B3
  • 别名：
    EI2BG_HUMAN antibody; EIF 2B antibody; eIF 2B GDP GTP exchange factor subunit gamma antibody; eIF-2B GDP-GTP exchange factor subunit gamma antibody; eIF2B-gamma antibody; Eif2b3 antibody; EIF2Bgamma antibody; Eukaryotic translation initiation factor 2B subunit 3 gamma antibody; Eukaryotic translation initiation factor 2B; gamma antibody; eukaryotic translation initiation factor 2B; subunit 3 gamma; 58kDa antibody; OTTHUMP00000010262 antibody; OTTHUMP00000010263 antibody; Translation initiation factor eIF-2B subunit gamma antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human eIF2Bγ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
  • 基因功能参考文献：
    1. To determine the tolerance differences to ERS, cell viability and apoptosis rates were detected in oligodendrocyte cell lines transfected with EIF2B3-c.1037T>C or the wild type. We confirmed that oligodendrocytes with mutant EIF2B3 was less tolerant to ERS than the wild type, with decreased cell viability and increased apoptosis rates. PMID: 26625702
    2. Results show significant higher incidence of Chinese patients with EIF2B3 mutations compared with Caucasian patients. The c.1037T>C in EIF2B3 was confirmed to be a founder mutation in Chinese explaining the genotypic differences between ethnicities. PMID: 25761052
  • 相关疾病：
    Leukodystrophy with vanishing white matter (VWM)
  • 蛋白家族：
    EIF-2B gamma/epsilon subunits family
  • 数据库链接：

    HGNC: 3259

    OMIM: 603896

    KEGG: hsa:8891

    STRING: 9606.ENSP00000353575

    UniGene: Hs.533549