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EIF2A Antibody

  • 货号：
    CSB-PA007509GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BY44
  • 基因名：
  • 别名：
    65 kDa eukaryotic translation initiation factor 2A antibody; CDA 02 antibody; CDA02 antibody; EIF 2 antibody; EIF 2A antibody; eIF-2A antibody; EIF2 antibody; eif2a antibody; EIF2A_HUMAN antibody; Eukaryotic translation initiation factor 2A 65kDa antibody; Eukaryotic translation initiation factor 2A antibody; MST089 antibody; MSTP004 antibody; MSTP089 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EIF2A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
  • 基因功能参考文献：
    1. Data suggest that neither eIF2A nor eIF2D are involved in the translation of this Sindbis virus subgenomic mRNA (sgmRNA) bearing non-AUG codons. PMID: 28240315
    2. HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation. PMID: 29233968
    3. POSTN may function as a protective factor for osteoblasts during this process by inhibiting the eIF2alphaATF4 pathway. PMID: 29207036
    4. findings indicate that MSI1 plays a leading role in stress granule formation that grants cancer stem cell properties and chemoresistant stress granules in GBM, in response to stressful conditions via the PKR/eIF2alpha signalling cascade. PMID: 29486283
    5. There was no statistically significant difference in IFN therapeutic effectiveness among the patients with different genotypes of eIF-2a-reg2. PMID: 17407708
    6. activation by mechanical force PMID: 15781241
    7. FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways PMID: 15961545

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  • 蛋白家族：
    WD repeat EIF2A family
  • 组织特异性：
    Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta.
  • 数据库链接：

    HGNC: 3254

    OMIM: 609234

    KEGG: hsa:83939

    STRING: 9606.ENSP00000417229

    UniGene: Hs.655782