EHD3 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) EHD3 Polyclonal antibody
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Uniprot No.:Q9NZN3
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基因名:
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别名:EHD3 antibody; EHD2 antibody; PAST3EH domain-containing protein 3 antibody; PAST homolog 3 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human EH domain-containing protein 3 protein (269-498AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,EHD3 Antibody (CSB-PA878940LA01HU),的标记方式是Non-conjugated。对于EHD3 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, IHC, IF
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 IF 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine receptor. Plays a role in cardiac...显示更多
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基因功能参考文献:
- Data provide evidence that EHD3 might undergo its tumor suppressor functions at least in part through promoting the sorting of activated EGFR to the lysosomal degradative compartment and spatio-temporal regulation of EGFR signaling via ERK and AKT. PMID: 27811356
- the residues Ala-519/Asp-520 of EHD1 and Asn-519/Glu-520 of EHD3 as defining the selectivity of these two paralogs for NPF-containing binding partners PMID: 27189942
- The EHD3 gene may be associated with the endophenotype of cognitive function in major depressive disorder patients. PMID: 24997812
- 3 SNPs present in the EHD3 gene, of which rs619002 and rs644926 were exclusively associated with female major depressive disorder PMID: 24607927
- demonstrate Ehd3 growth inhibitory functions in glioma cells in vivo. We suggest that Ehd3 functions as a tumor suppressor gene and loss of its expression is a very common event in gliomas PMID: 24306026
- The combined effect of the EHD3 and FREM3 genes may play an important role in developing major depressive disorder. PMID: 22337703
- EHD3 is a previously unrecognized component of the cardiac remodeling pathway in heart failure. PMID: 22406195
- presented herein promote a coordinated role for EHD proteins and Rab11-FIP2 in mediating endocytic recycling and provide evidence for the function of EHD3 in early endosome to endocytic recycling compartment transport PMID: 16251358
- Our findings support a role for EHD3 in regulating endosome-to-Golgi transport, and as a consequence, lysosomal biosynthetic, but not secretory, transport pathways are also affected PMID: 19139087
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亚细胞定位:Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side.
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蛋白家族:TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, EHD subfamily
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组织特异性:Highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta.
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数据库链接:
HGNC: 3244
OMIM: 605891
KEGG: hsa:30845
STRING: 9606.ENSP00000327116
UniGene: Hs.368808