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EHD2 Antibody

  • 货号：
    CSB-PA007491GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NZN4
  • 基因名：
  • 别名：
    EH domain containing 2 antibody; EH domain containing 3 antibody; EH domain containing protein 2 antibody; EH domain-containing protein 2 antibody; EHD 2 antibody; Ehd2 antibody; EHD2_HUMAN antibody; EHD3 antibody; FLJ96617 antibody; PAST 2 antibody; PAST homolog 2 antibody; PAST2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EHD2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane.
  • 基因功能参考文献：
    1. Our prognostic model is useful for predicting persistent/recurrent disease after surgery of Papillary thyroid carcinoma (PTC). EHD2 mRNA expression could be a novel prognostic marker for PTC patients. PMID: 28358874
    2. EHD2 expression, along with the epithelial marker E-cadherin, was markedly reduced in tumor tissues than in adjacent noncancerous tissues. Molecular data indicated that EHD2 inhibited migration and invasion of hepatocellular carcinoma probably by interacting with E-cadherin. PMID: 27221498
    3. Data suggest that the EH-domain containing 2 protein (EHD2) NPF phenylalanine residue is crucial for EHD2 localization to the plasma membrane, whereas the proline residue is essential for EHD2 dimerization and binding. PMID: 25875965
    4. EHD2 can inhibit the metastasis of human breast cancer by regulating the epithelial-to-mesenchymal transition markers E-cadherin and N-cadherin. PMID: 25758127
    5. Downregulation of EHD2 was associated with migration and invasion by abrogating the expression of Rac1 in breast cancer patients. PMID: 25557791
    6. Phosphatidylinositol 4,5-bisphosphate controls EHD2 plasma membrane localization. PMID: 24040268
    7. Our results suggested that EHD2 low expression is involved in the pathogenesis of human esophageal squamous cell carcinoma PMID: 23354948
    8. EHD2 participates in the sarcolemma repair. PMID: 22679923
    9. Assembly of EHD2 stabilized and constrained caveolae to the plasma membrane to control turnover, and depletion of EHD2, resulting in endocytic and more dynamic and short-lived caveolae. PMID: 22323287
    10. Among three EHD proteins (EHD1-EHD3) that were tested, only EHD2 accumulates in the nucleus under nuclear export inhibition treatment. PMID: 22448906
    11. Confining caveolae to the plasma membrane by EHD2 relied on its capacity to link caveolae to actin filaments. PMID: 22505029
    12. EHD2 regulates trafficking from the plasma membrane by controlling Rac1 activity. PMID: 21756249

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, caveola; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, EHD subfamily
  • 组织特异性：
    Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle.
  • 数据库链接：

    HGNC: 3243

    OMIM: 605890

    KEGG: hsa:30846

    STRING: 9606.ENSP00000263277

    UniGene: Hs.744963