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EFNA4 Antibody

  • 货号：
    CSB-PA002373
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using Ephrin-A4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P52798
  • 基因名：
  • 别名：
    EFL 4 antibody; EFL4 antibody; EFN A4 antibody; EFNA 4 antibody; EFNA4 antibody; EFNA4_HUMAN antibody; Eph related receptor tyrosine kinase ligand 4 antibody; EPH-related receptor tyrosine kinase ligand 4 antibody; Ephrin-A4 antibody; EphrinA4 antibody; EPLG 4 antibody; EPLG4 antibody; LERK 4 antibody; LERK-4 antibody; LERK4 antibody; Ligand of Eph related kinase 4 antibody; MGC125826 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Ephrin-A4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
  • 基因功能参考文献：
    1. Study present for the first time in vitro and in vivo evidence suggesting that the major role of two ephrin A4 isoforms in chronic lymphocytic leukemia could be related with a non-previously described mechanism of survival linked to extravasation strongly dependent on integrin signaling. PMID: 27374180
    2. The cytoplasmic pattern of ephrin A4 could identify a subgroup of primary osteosarcoma patients with a high liability for progression, poor prognosis, and inferior response to chemotherapy. PMID: 20071790
    3. Characterization of the promoter PMID: 12030849
    4. This provides genetic evidence that Twist1, Msx2 and Efna4 function together in boundary formation and the pathogenesis of coronal synostosis. PMID: 16540516
    5. CLL B-cells showed a more heterogeneous Eph/EFN profile, specially EFNA4, EphB6 and EphA10. EphB6 and EFNA4 were further related with the clinical course of CLL. PMID: 18819711
    6. EFNA4-EphA2 interactions are involved in Chronic lymphocytic leukemia cell trafficking between blood and the tissues PMID: 19828693

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 2]: Secreted.
  • 蛋白家族：
    Ephrin family
  • 组织特异性：
    Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
  • 数据库链接：

    HGNC: 3224

    OMIM: 601380

    KEGG: hsa:1945

    STRING: 9606.ENSP00000414378

    UniGene: Hs.449913