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EDN3 Antibody

  • 货号：
    CSB-PA066402
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA066402(EDN3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA066402(EDN3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P14138
  • 基因名：
    EDN3
  • 别名：
    EDN3 antibody; EDN3_HUMAN antibody; Endothelin 3 antibody; Endothelin-3 antibody; ET 3 antibody; ET-3 antibody; PPET3 antibody; Preproendothelin 3 antibody; Preproendothelin-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human EDN3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Endothelins are endothelium-derived vasoconstrictor peptides.
  • 基因功能参考文献：
    1. the critical physiological role of the KIT-ET3-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported. PMID: 28880927
    2. genome-wide association studies in population of women in China: Data suggest that EDN3 (endothelin 3) and EDNRB (endothelin receptor type B) play important roles in the molecular mechanisms underlying cervical cancer. PMID: 27863272
    3. EDN3 expression in left internal mammary arteries depends on tissue harvesting technique. PMID: 24647318
    4. Down-regulated expression of ET3 attenuates the malignant behaviors of human melanoma cells partially by decreasing the expression of SPARC. PMID: 23904381
    5. Waardenburg syndrome type II and mutations of EDNRB, EDN3 and SOX10 genes are responsible for Waardenburg syndrome type IV. (review) PMID: 24379252
    6. Our data showed that almost all patients, regardless of individual characteristics such as gender or age, expressed the endothelin receptor genes, but did not express the genes for ET-3. PMID: 23515723
    7. These data suggest that autocrine EDN3/EDNRB signaling is essential for maintaining GSCs. Incorporating END3/EDNRB-targeted therapies into conventional cancer treatments may have clinical implication for the prevention of tumor recurrence. PMID: 22013079
    8. Finding suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and that the EDN3 mutation acts as a phenotype modifier. PMID: 19556619
    9. EDN3 may be considered as a common susceptibility gene for sporadic Hirschsprung disease in a low-penetrance fashion. PMID: 20009762
    10. Mutations are found in Hirschsprung's disease in a Chinese population. PMID: 14669347
    11. KEL6 red blood cells have endothelin-3-converting enzyme activity PMID: 16423827
    12. neither polymorphism nor mutation was observed in EDN3 in Chinese Hirschprung disease patients PMID: 17554617
    13. Endothelin-3 molecule is specifically upregulated in metastatic melanoma cells, showing that an abnormal autocrine stimulation pathway involving ET-3 is present in metastatic melanoma cells. PMID: 18346402
    14. Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells. PMID: 18722093
    15. ET3 induced activation of IkappaB & MAPK in epithelial cells. ET3 is involved in regulating human colonic epithelial cell proliferation & survival, particularly for goblet cells. PMID: 18832450
    16. In conclusion, Multiplex Ligation-dependent Probe Amplification assessment of rearrangements in the RET proto-oncogene and in 3 other associated genes, ZEB2, EDN3 and GDNF did not show any variants in 80 sporadic Hirschsprung disease patients. PMID: 19183406
    17. Report on spanish cases of Waardenburg syndrome type 4 with novel mutations in EDN3 and SOX 10 genes. PMID: 19764030

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  • 相关疾病：
    Hirschsprung disease 4 (HSCR4); Congenital central hypoventilation syndrome (CCHS); Waardenburg syndrome 4B (WS4B)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Endothelin/sarafotoxin family
  • 组织特异性：
    Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
  • 数据库链接：

    HGNC: 3178

    OMIM: 131242

    KEGG: hsa:1908

    STRING: 9606.ENSP00000337128

    UniGene: Hs.1408