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ECI2 Antibody

  • 货号：
    CSB-PA002204
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using DRS-1 Polyclonal Antibody
    • Western Blot analysis of K562 cells using DRS-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O75521
  • 基因名：
    ECI2
  • 别名：
    2-trans-enoyl-CoA isomerase antibody; ACBD2 antibody; acyl Coenzyme A binding domain containing 2 antibody; D2-enoyl-CoA isomerase antibody; D3 antibody; D3 D2 enoyl CoA isomerase antibody; DBI related protein 1 antibody; DBI-related protein 1 antibody; delta(2)-enoyl-CoA isomerase antibody; Delta(3) antibody; Delta(3) delta(2) enoyl CoA isomerase antibody; Diazepam-binding inhibitor-related protein 1 antibody; Dodecenoyl CoA isomerase antibody; Dodecenoyl-CoA isomerase antibody; DRS 1 antibody; DRS-1 antibody; DRS1 antibody; Eci2 antibody; ECI2_HUMAN antibody; Enoyl-CoA delta isomerase 2 antibody; HCA88 antibody; Hepatocellular carcinoma associated antigen 88 antibody; Hepatocellular carcinoma-associated antigen 88 antibody; mitochondrial antibody; pECI antibody; Peroxisomal 3 antibody; Peroxisomal 3,2-trans-enoyl-CoA isomerase antibody; Peroxisomal D3 D2 enoyl CoA isomerase antibody; Renal carcinoma antigen NY REN 1 antibody; Renal carcinoma antigen NY-REN-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human DRS-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.
  • 基因功能参考文献：
    1. Enoyl-CoA delta isomerase 2 (ECI2) is a novel AR-target that promotes prostate cancer cell survival PMID: 28415728
    2. Ectopic expression of the ACBD2/ECI2 isoform A in MA-10 cells led to increased basal and hormone-stimulated steroid formation, indicating that ACBD2/ECI2-mediated peroxisomes-mitochondria interactions favor in the exchange of metabolites and/or macromolecules between these 2 organelles in support of steroid biosynthesis. Considering the widespread occurrence of the ACBD2/ECI2 protein, we propose that this protein might se PMID: 27167610
    3. Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse PMID: 11916962
    4. DRS-1 may serve as an autoantigen eliciting immune attack against hematopoietic stem cells in a subset of acquired aplastic anemia patients characterized by increased paroxysmal nocturnal hemoglobinuria-type cells PMID: 15217832
  • 亚细胞定位：
    [Isoform 1]: Mitochondrion.; [Isoform 2]: Peroxisome matrix.
  • 蛋白家族：
    Enoyl-CoA hydratase/isomerase family
  • 组织特异性：
    Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.
  • 数据库链接：

    HGNC: 14601

    OMIM: 608024

    KEGG: hsa:10455

    STRING: 9606.ENSP00000369461

    UniGene: Hs.15250