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DYNC1LI1 Antibody

  • 中文名称：
    DYNC1LI1兔多克隆抗体
  • 货号：
    CSB-PA897312LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA897312LA01HU diluted at 1:200 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DYNC1LI1 Polyclonal antibody
  • Uniprot No.：
    Q9Y6G9
  • 基因名：
    DYNC1LI1
  • 别名：
    Cytoplasmic dynein 1 light intermediate chain 1 antibody; cytosolic antibody; DC1L1_HUMAN antibody; DLC-A antibody; DNCLI1 antibody; dync1li1 antibody; Dynein cytoplasmic 1 light intermediate chain 1 antibody; Dynein cytoplasmic light intermediate polypeptide 1 antibody; Dynein light chain A antibody; Dynein light intermediate chain 1 antibody; Dynein light intermediate chain 1 cytosolic antibody; FLJ10219 antibody; LIC1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cytoplasmic dynein 1 light intermediate chain 1 protein (167-233AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DYNC1LI1 Antibody (CSB-PA897312LA01HU)，的标记方式是Non-conjugated。对于DYNC1LI1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA897312LB01HU DYNC1LI1 Antibody, HRP conjugated ELISA
    FITC CSB-PA897312LC01HU DYNC1LI1 Antibody, FITC conjugated
    Biotin CSB-PA897312LD01HU DYNC1LI1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.
  • 基因功能参考文献：
    1. conserved mechanism of effector interaction with dynein-dynactin necessary for processive motility PMID: 29515126
    2. the DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. PMID: 27510948
    3. This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. PMID: 27482052
    4. although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. PMID: 25422374
    5. using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway. PMID: 21169557
    6. Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells. PMID: 20026645
    7. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint PMID: 19229290

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  • 亚细胞定位：
    Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    Dynein light intermediate chain family
  • 数据库链接：

    HGNC: 18745

    OMIM: 615890

    KEGG: hsa:51143

    STRING: 9606.ENSP00000273130

    UniGene: Hs.529495