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DYNC1I1 Antibody

  • 货号：
    CSB-PA007293ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DYNC1I1 antibody at 2.52µg/ml
      Lane 1: Mouse brain tissue
      Lane 2: Mouse gonadal tissue
      Lane 3: K562 whole cell lysate
      Lane 4: HL60 whole cell lysate
      Lane 5: Mouse lung tissue
      Lane 6: Mouse skeletal muscle tissue
      Lane 7: Mouse stomach tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 73, 71, 69, 68 kDa
      Observed band size: 73 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007293ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA007293ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DYNC1I1 Polyclonal antibody
  • Uniprot No.：
    O14576
  • 基因名：
    DYNC1I1
  • 别名：
    Cytoplasmic dynein 1 intermediate chain 1 antibody; Cytoplasmic dynein intermediate chain 1 antibody; cytosolic antibody; DC1I1_HUMAN antibody; DH IC 1 antibody; DH IC-1 antibody; DH IC1 antibody; DNCI1 antibody; DNCIC1 antibody; Dync1i1 antibody; Dynein cytoplasmic 1 intermediate chain 1 antibody; Dynein intermediate chain 1 antibody; Dynein intermediate chain 1; cytosolic antibody; Dynein; cytoplasmic; intermediate polypeptide 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Cytoplasmic dynein 1 intermediate chain 1 protein (1-220AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
  • 基因功能参考文献：
    1. SQSTM1 is required for proper dynein motility and trafficking along microtubules. PMID: 25015291
    2. Deletions of the exons with regulatory potential of DYNC1I1 are an example of the emerging role of exonic enhancer elements and their implications in congenital malformation syndromes PMID: 25231166
    3. NCAM and dynein have roles in tethering dynamic microtubules and maintaining synaptic density in cortical neurons PMID: 23960070
    4. Both P-TEFb recruitment to the HIV long terminal repeat and enhanced HIV processivity were blocked by ERK inhibitor, but not by AKT and PI3K inhibitors. PMID: 21763495
    5. the mRNA expression level of DYNC1I1 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts. PMID: 21767414
    6. NDE1 and NDEL1 act upstream of LIS1 in dynein recruitment, and/or activation, on the membrane. PMID: 20048338
    7. identification of a novel 24-kDa protein that binds directly to dynein intermediate chain [PLAC-24] PMID: 12006665

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  • 亚细胞定位：
    Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    Dynein intermediate chain family
  • 数据库链接：

    HGNC: 2963

    OMIM: 603772

    KEGG: hsa:1780

    STRING: 9606.ENSP00000320130

    UniGene: Hs.440364