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DUSP7 Antibody

  • 货号：
    CSB-PA613702ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Dual specificity protein phosphatase 7 antibody at 10μg/ml + HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45, 41 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA613702ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA613702ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DUSP7 Polyclonal antibody
  • Uniprot No.：
    Q16829
  • 基因名：
  • 别名：
    Dual specificity phosphatase 7 antibody; Dual specificity protein phosphatase 7 antibody; Dual specificity protein phosphatase PYST2 antibody; DUS7_HUMAN antibody; Dusp7 antibody; Jnk Stimulatory Phosphatase 1 antibody; JSP1 antibody; MAP kinase phosphatase X antibody; MKPX antibody; PYST2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dual specificity protein phosphatase 7 protein (160-419AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2. Also has lower activity towards MAPK14 and MAPK8. In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex.
  • 基因功能参考文献：
    1. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of early arthritis. PMID: 28253537
    2. high levels of Pyst2-L detected in the active state of AML and ALL diseases and in other types of cancer reflect an altered MAPK signaling pathway in such malignant processes PMID: 14576828
    3. overexpressed in acute myelogenous leukemia PMID: 14674243
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 组织特异性：
    Strongly expressed in liver. Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.
  • 数据库链接：

    HGNC: 3073

    OMIM: 602749

    KEGG: hsa:1849

    STRING: 9606.ENSP00000417183

    UniGene: Hs.591664