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DUSP23 Antibody

  • 货号：
    CSB-PA929092
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA929092(DUSP23 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA929092(DUSP23 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9BVJ7
  • 基因名：
    DUSP23
  • 别名：
    Dual specificity phosphatase 23 antibody; Dual specificity protein phosphatase 23 antibody; DUS23_HUMAN antibody; Dusp23 antibody; DUSP25 antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody; FLJ20442 antibody; LDP 3 antibody; LDP-3 antibody; LDP3 antibody; Low molecular mass dual specificity phosphatase 3 antibody; MOSP antibody; RP11-190A12.1 antibody; VH1 like member Z antibody; VH1 like phosphatase Z antibody; VH1-like phosphatase Z antibody; VHZ antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human DUSP23
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
  • 基因功能参考文献：
    1. this study shows that DUSP23 mRNA levels in CD4+ T cells are higher in the systemic lupus erythematosus patients PMID: 27737517
    2. The upregulation of VHZ levels in primary human cancers supports the clinical relevance of this protein in cancers PMID: 20509867
    3. DUSP23 showed distinctive phosphatase activity toward p-nitrophenyl phosphate, as well as oligopeptides containing phospho-tyrosine and phospho-threonine residues. Furthermore, DUSP23 could dephosphorylate p44ERK1 but not p38 and p54SAPKbeta in vitro PMID: 15147733
    4. the smallest active protein-tyrosine phosphatase yet (only 16 kDa) belongs to the group of small Vaccinia virus VH1-related dual specific phosphatases; gene is located on human chromosome 1q23.1 and consists of only two coding exons PMID: 15201283
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 组织特异性：
    Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.
  • 数据库链接：

    HGNC: 21480

    KEGG: hsa:54935

    STRING: 9606.ENSP00000357087

    UniGene: Hs.425801