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DTNB Antibody

  • 货号：
    CSB-PA187891
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 823 cells, Primary antibody: CSB-PA187891(DTNB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    O60941
  • 基因名：
    DTNB
  • 别名：
    Beta dystrobrevin antibody; Beta-dystrobrevin antibody; DTN B antibody; DTN-B antibody; Dtnb antibody; DTNB_HUMAN antibody; Dystrobrevin beta antibody; MGC17163 antibody; MGC57126 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human DTNB
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses.
  • 基因功能参考文献：
    1. Data provide new insights into the role of beta-dystrobrevin in the molecular mechanisms underlying neuronal differentiation that could be relevant in the establishment of the cognitive impairment in Duchene muscular dystrophy. PMID: 27223470
    2. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35 PMID: 20530487
    3. results suggest that dysbindin assembled into BLOC-1 is not a physiological binding partner of the dystrobrevins, likely due to engagement of its dystrobrevin-binding region in interactions with other subunits PMID: 16448387
  • 亚细胞定位：
    Cytoplasm. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Basal cell membrane. Cell junction, synapse, postsynapse. Nucleus.
  • 蛋白家族：
    Dystrophin family, Dystrobrevin subfamily
  • 组织特异性：
    Highly expressed in brain, kidney and pancreas.
  • 数据库链接：

    HGNC: 3058

    OMIM: 602415

    KEGG: hsa:1838

    STRING: 9606.ENSP00000384084

    UniGene: Hs.307720