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DSCAM Antibody

  • 货号：
    CSB-PA007192LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA007192LA01HU diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA007192LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DSCAM Polyclonal antibody
  • Uniprot No.：
    O60469
  • 基因名：
    DSCAM
  • 别名：
    CHD2 42 antibody; CHD2 52 antibody; CHD2 antibody; Down syndrome cell adhesion molecule antibody; DSCAM antibody; DSCAM_HUMAN antibody; human CHD2-52 down syndrome cell adhesion molecule 2; 9 antibody; OTTHUMP00000109193 2 antibody; SD11109p antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Down syndrome cell adhesion molecule protein (1711-1867AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DSCAM Antibody (CSB-PA007192LA01HU)，的标记方式是Non-conjugated。对于DSCAM Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007192LB01HU DSCAM Antibody, HRP conjugated ELISA
    FITC CSB-PA007192LC01HU DSCAM Antibody, FITC conjugated
    Biotin CSB-PA007192LD01HU DSCAM Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC. In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.
  • 基因功能参考文献：
    1. Our study did not repeatedly confirm the association of the rs2222973 or the rs11770843 SNP with adolescent idiopathic scoliosis in a Chinese Han population. PMID: 25408124
    2. The most significant was DSCAM, a neurological gene expressed widely in the developing brain and in the amygdala and hippocampus of the adult brain. PMID: 25867994
    3. DSCAM physically interacts with tubulin folding cofactor D. PMID: 25653356
    4. DSCAM as a Hirschsprung disease (HSCR) susceptibility locus, both in Down syndrome and HSCR isolated cases. PMID: 23671607
    5. Down syndrome cell adhesion molecule interacts with PRKAG1 subunit and plays an important role in netrin-1 induced neurite outgrowth. PMID: 23479427
    6. knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1 PMID: 22685302
    7. The specificity of Drosophila Dscam is due to complementarity of variable residues in epitope I. PMID: 17721508
    8. Overall, our study found a significant association of IL-17RC gene polymorphisms with AIS in a Chinese Han population, indicating IL-17RC gene may be as a susceptibility gene for AIS. PMID: 22744455
    9. Dscam may be involved in the generation and development of intractable epilepsy. PMID: 21360594
    10. functionally conserved with Drosophila Dscam[TM1] isoforms PMID: 21645617
    11. A specific promoter region directs expression of DSCAM in the developing choroid plexus and roof of the fourth ventricle, the floor plate of the fourth ventricle, pons and medulla oblongata, and the eye, limb buds, and dorsal root ganglion PMID: 12435380
    12. These results suggest the possible contribution of DSCAM gene in bipolar disorder. PMID: 18197079
    13. findings demonstrate an essential role of vertebrate DSCAM in axon guidance, indicating that DSCAM functions as a receptor of netrin-1 PMID: 19196994
    14. Dscam transgene with or without exon 19 in its endodomain is used to govern different stage-specific neuronal morphogenetic processes, possibly due to differences in protein targeting. PMID: 19211897
    15. In all transgenic retinal cell types examined, both DSCAM and DSCAM-LIKE1 genes are functioning similarly in self-avoidance, whereas the stratification of neurites and synaptic specificity are intact in their absence. PMID: 19945391

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  • 亚细胞定位：
    [Isoform Short]: Secreted.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Cell projection, growth cone. Cell junction, synapse.
  • 组织特异性：
    Primarily expressed in brain.
  • 数据库链接：

    HGNC: 3039

    OMIM: 602523

    KEGG: hsa:1826

    STRING: 9606.ENSP00000383303

    UniGene: Hs.160418