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DSC3 Antibody

  • 货号：
    CSB-PA613507LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA613507LA01HU diluted at 1:400 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA613507LA01HU diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA613507LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DSC3 Polyclonal antibody
  • Uniprot No.：
    Q14574
  • 基因名：
    DSC3
  • 别名：
    Cadherin family member 3 antibody; CDHF3 antibody; desmocollin 3a/3b antibody; Desmocollin 4 antibody; Desmocollin-3 antibody; Desmocollin-4 antibody; Desmocollin3 antibody; Desmocollin4 antibody; DSC antibody; DSC1 antibody; DSC2 antibody; DSC3 antibody; DSC3_HUMAN antibody; DSC4 antibody; HT CP antibody; HT-CP antibody; HTCP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Desmocollin-3 protein (712-896AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DSC3 Antibody (CSB-PA613507LA01HU)，的标记方式是Non-conjugated。对于DSC3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA613507LB01HU DSC3 Antibody, HRP conjugated ELISA
    FITC CSB-PA613507LC01HU DSC3 Antibody, FITC conjugated
    Biotin CSB-PA613507LD01HU DSC3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
  • 基因功能参考文献：
    1. The Findings of this study imply early alteration of the substantia nigra in XDP mutation carriers prone to develop parkinsonism. PMID: 28094105
    2. Data show that fetal pMSCs (mesenchymal stromal cells) expressing the highest levels of desmoglein 2, desmocollin 3 and plakophilin 2, followed by maternal pMSCs, while bmMSCs expressed the lowest levels. PMID: 28154962
    3. Napsin-A, and Desmocollin-3 were sensitive and specific markers for the diagnosis of AC and SCC, respectively. Both markers allowed classification of 54/60 cases into either AC or SCC. PMID: 26710975
    4. Suggest that Dsc3 can mediate FSH-induced ovarian cancer cell proliferation by activating the EGFR/Akt signaling pathway. PMID: 26261554
    5. data suggests that DNA methylation contributes to down-regulation of DSC3 in prostate cancer, and loss of DSC3 predicts poor clinical outcome. PMID: 24664224
    6. The data show an important role of physiologically occurring transcript d2-d4 in normal brain function. Interference with this role by DSC3 is a likely pathological mechanism in X-chromosomal dystonia parkinsonism syndrome PMID: 23184149
    7. The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer. PMID: 22941060
    8. These findings demonstrate that IgG autoantibodies against an additional component of the desmosomes, Dsc3, induce loss of keratinocyte adhesion and thus may contribute to blister formation in pemphigus. PMID: 21281804
    9. Methylation status of DSC3 DNA is a prognostic marker for colorectal cancer. P53 appears to have an important role in regulating DSC3 expression. PMID: 21364582
    10. Autoimmunity to DSC3 in Pemphigus vulgaris. PMID: 20952584
    11. Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters PMID: 12789271
    12. Lss of DSC3 expression is a common event in primary breast tumor specimens, and DSC3 gene silencing in breast tumors is frequently linked to aberrant cytosine methylation and concomitant changes in chromatin structure. PMID: 16168112
    13. Increased Dsc3 protein is associated with colorectal cancer PMID: 17088906
    14. results suggest an abnormal expression of Dsc3, Dsg3, & beta-catenin induced in the progression of oral carcinomas & that Dsc3 expression level might be related to the regulation of beta-catenin in lymph node metastasis and cell proliferation in OSCCs. PMID: 17846785
    15. Desmocollin-3 was expressed in almost half of the undifferentiated large-cell cancers PMID: 19287461
    16. Both the binding of desmocollin 3 (Dsc3) to plakoglobin and Dsc3 phosphorylation are involved in Dsc3 binding to desmoglein 3 (Dsg3) during Ca2+ -induced desmosome assembly. PMID: 19348003
    17. loss of heterophilic Dsc3/Dsg1 binding may contribute to pemphigus skin blistering PMID: 19717567
    18. a human desmocollin-3 (DSC3) nonsense mutation underlies hereditary hypotrichosis and recurrent skin vesicles PMID: 19765682

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  • 相关疾病：
    Hypotrichosis and recurrent skin vesicles (HRSV)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 组织特异性：
    Epidermis, buccal mucosa, esophagus and cervix.
  • 数据库链接：

    HGNC: 3037

    OMIM: 600271

    KEGG: hsa:1825

    STRING: 9606.ENSP00000353608

    UniGene: Hs.41690