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DR1 Antibody

  • 货号：
    CSB-PA007175ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DR1 antibody at 2.32μg/ml
      Lane 1: Rat gonad tissue
      Lane 2: PC-3 whole cell lysate
      Lane 3: Hela whole cell lysate
      Lane 4: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 19 kDa
      Observed band size: 23, 26 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007175ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA007175ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DR1 Polyclonal antibody
  • Uniprot No.：
    Q01658
  • 基因名：
    DR1
  • 别名：
    Down regulator of transcription 1 antibody; Down regulator of transcription 1 TBP binding antibody; Down-regulator of transcription 1 antibody; down-regulator of transcription 1; TBP-binding (negative cofactor 2) antibody; DR 1 antibody; Dr1 antibody; Dr1 protein antibody; NC 2 antibody; NC2 antibody; NC2 beta antibody; NC2-beta antibody; NC2B_HUMAN antibody; Negative co factor 2 antibody; Negative cofactor 2 antibody; Negative cofactor 2 beta antibody; Negative cofactor 2-beta antibody; Protein Dr1 antibody; TATA binding protein associated phosphoprotein antibody; TATA box/binding protein associated phosphoprotein DR1 antibody; TATA-binding protein-associated phosphoprotein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Protein Dr1 protein (1-176AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
  • 基因功能参考文献：
    1. results suggest that DR1 are expressed in the osteosarcoma cells and inhibit the proliferation of osteosarcoma cells by the down-regulation of the ERK1/2 and PI3K-Akt pathways. PMID: 28181134
    2. Knockdown of DR1 resulted in reductions of viral RNA and protein production, demonstrating that DR1 acts as a positive host factor in influenza A virus replication. PMID: 25589657
    3. Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells. PMID: 20230619
    4. The physiological functions of human Dr1 include regulation of polymerase III transcription. PMID: 19965767
    5. NC2 controls TBP binding and maintenance on DNA that is largely independent of a canonical TATA sequence PMID: 15574413
    6. the initiator core promoter element antagonizes repression of TATA-directed transcription by negative cofactor NC2 PMID: 17584739
    7. Data show that NC2beta is specifically involved in neuroblastoma pathogenesis and may be considered a new neuroblastoma biomarker. PMID: 18538002
    8. ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein PMID: 18838386
    9. heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex PMID: 19204005

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NC2 beta/DR1 family
  • 数据库链接：

    HGNC: 3017

    OMIM: 601482

    KEGG: hsa:1810

    STRING: 9606.ENSP00000359290

    UniGene: Hs.348418