Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. DPY19L2 Antibody

DPY19L2 Antibody

  • 货号：
    CSB-PA757514LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA757514LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DPY19L2 Polyclonal antibody
  • Uniprot No.：
    Q6NUT2
  • 基因名：
    DPY19L2
  • 别名：
    DPY19L2 antibody; UNQ3127/PRO10284 antibody; Probable C-mannosyltransferase DPY19L2 antibody; EC 2.4.1.- antibody; Dpy-19-like protein 2 antibody; Protein dpy-19 homolog 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Probable C-mannosyltransferase DPY19L2 protein (599-749AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DPY19L2 Antibody (CSB-PA757514LA01HU)，的标记方式是Non-conjugated。对于DPY19L2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA757514LB01HU DPY19L2 Antibody, HRP conjugated ELISA
    FITC CSB-PA757514LC01HU DPY19L2 Antibody, FITC conjugated
    Biotin CSB-PA757514LD01HU DPY19L2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation.
  • 基因功能参考文献：
    1. Low PLCZ1 expression is associated with globozoospermia with DPY19L2 deletion. PMID: 29339016
    2. provide new evidence, on the one hand, for a severe lack of maturation of the NL, and on the other hand, for dramatic modifications in the location of chromatin-related NL partners in DPY19L2-deleted spermatozoa PMID: 28882431
    3. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
    4. Among Tunisian patients with globozoospermia, 8 DPY19L2 haplotypes were found. 61.1% were homozygous for a DPY19L2 deletion. A new splice-site mutation at the junction exon-intron 16 [c.1579_1580+4delAGGTAAinsTCAT] was found in 1 patient. PMID: 26516168
    5. The DPY19L2 mutations are the major cause of globozoospermia. PMID: 23512994
    6. Analysis of public databases at the DPY19L2 locus paradoxically revealed that, in the general population, duplications were approximately three times as frequent as deletions. PMID: 23555282
    7. DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene. PMID: 22653751
    8. identification of DPY19L2 deletions and point mutations in European patients shows that globozoospemia caused by a molecular defect of DPY19L2 can be expected in individuals from any ethnic background PMID: 22627659
    9. Patients with globozoospermia have a homozygous deletion of DPY19L2. PMID: 21397064
    10. The relocation of the gene DPY19L2 within a set of low copy repeats. PMID: 16526957

    显示更多

    收起更多

  • 相关疾病：
    Spermatogenic failure 9 (SPGF9)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Dpy-19 family
  • 组织特异性：
    Widely expressed with high expression in testis. Not detectable in ejaculated sperm (at protein level).
  • 数据库链接：

    HGNC: 19414

    OMIM: 613893

    KEGG: hsa:283417

    STRING: 9606.ENSP00000315988

    UniGene: Hs.533644