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DOK3 Antibody

  • 货号：
    CSB-PA007019LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse heart tissue, Human placenta tissue
      All lanes: DOK3 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 54, 24, 36, 25 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA007019LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA007019LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The DOK3 antibody is generated from rabbits immunized with a peptide corresponding to amino acids 1-146 of the recombinant DOK3 protein. It is a polyclonal antibody and occurs as an unconjugated IgG. Its purity is over 95% using protein G purified. It can react with human and mouse samples. The target protein DOK3 is an adaptor molecule preferentially expressed in hematopoietic cells, which act as a cell type–specific regulator downstream of various immune receptors, including TLR3, TLR4, and B cell receptor (BCR), during viral infection, LPS stimulation as well as plasma cell differentiation. And DOK3 is dispensable for the development of immune cells. And this DOK3 antibody can be used to detect the DOK3 protein in ELISA, WB, IHC, and IF analyses.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DOK3 Polyclonal antibody
  • Uniprot No.：
    Q7L591
  • 基因名：
    DOK3
  • 别名：
    Docking protein 3 antibody; DOK 3 antibody; DOK Like Protein antibody; Dok3 antibody; DOK3_HUMAN antibody; DOKL Pending antibody; Downstream of tyrosine kinase 3 antibody; p62 DOK Like Protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Docking protein 3 protein (1-146AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DOK3 Antibody (CSB-PA007019LA01HU)，的标记方式是Non-conjugated。对于DOK3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007019LB01HU DOK3 Antibody, HRP conjugated ELISA
    FITC CSB-PA007019LC01HU DOK3 Antibody, FITC conjugated
    Biotin CSB-PA007019LD01HU DOK3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function.
  • 基因功能参考文献：
    1. Mutations in DOK3 gene is associated with prostate cancer PMID: 26585945
    2. DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells. PMID: 27265473
    3. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters PMID: 23223229
    4. absence of DOK3 increases LPS signaling, contributing to LPS-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions PMID: 22761938
    5. Identification of DOK genes as lung tumor suppressors. PMID: 20139980
    6. The novel platelet adapter Dok-3 is tyrosine phosphorylated in an Src kinase-independent manner downstream of alphaIIbbeta3 in human platelets, leading to an interaction with Grb2 and SHIP-1. PMID: 19682241
    7. findings indicate that Dok-3 sequesters Grb2 from Shc and inhibits the Ras-Erk pathway downstream of PTKs PMID: 16436051

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    DOK family, Type A subfamily
  • 组织特异性：
    Expressed in spleen.
  • 数据库链接：

    HGNC: 24583

    OMIM: 611435

    KEGG: hsa:79930

    STRING: 9606.ENSP00000349727

    UniGene: Hs.720849