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DOCK7 Antibody

  • 货号：
    CSB-PA007103GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96N67
  • 基因名：
    DOCK7
  • 别名：
    DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DOCK7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3.
  • 基因功能参考文献：
    1. these results suggest that the DOCK-ANGPTL3 SNPs and their haplotypes were associated with the angiographic severity to coronary artery atherosclerosis and the risk of coronary artery disease (CAD) and ischemic stroke in the Southern Chinese Han population. PMID: 29454388
    2. Possible inter-locus interactions among the DOCK7, PCSK9 and GALNT2 SNPs were also noted. PMID: 26493351
    3. Differences in lipid profiles between the Jing and Han populations might partially attribute to the DOCK7, PCSK9 and GALNT2 gene polymorphisms and their haplotypes determining different risk for the development of cardiovascular diseases. PMID: 26744084
    4. Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. PMID: 27018747
    5. These observations suggest that loss of DOCK7 function causes a syndromic form of epileptic encephalopathy by affecting multiple neuronal processes. PMID: 24814191
    6. Dock7 mediates serum- and HGF-induced glioblastoma cell invasion. PMID: 24518591
    7. DOCK7 functions as an essential and downstream regulator of RAGE-mediated cellular migration through the formation of dendritic pseudopodia. PMID: 23254359
    8. The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex. PMID: 23718289
    9. Dock7 functions as an intracellular substrate for ErbB2 to promote Schwann cell migration. PMID: 18426980

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  • 相关疾病：
    Epileptic encephalopathy, early infantile, 23 (EIEE23)
  • 亚细胞定位：
    Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.
  • 蛋白家族：
    DOCK family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 19190

    OMIM: 615730

    KEGG: hsa:85440

    STRING: 9606.ENSP00000340742

    UniGene: Hs.744927