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DOCK10 Antibody

  • 货号：
    CSB-PA842645LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA842645LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DOCK10 Polyclonal antibody
  • Uniprot No.：
    Q96BY6
  • 基因名：
    DOCK10
  • 别名：
    DOCK10 antibody; KIAA0694 antibody; ZIZ3Dedicator of cytokinesis protein 10 antibody; Zizimin-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DOCK10 Antibody (CSB-PA842645LA01HU)，的标记方式是Non-conjugated。对于DOCK10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA842645LB01HU DOCK10 Antibody, HRP conjugated ELISA
    FITC CSB-PA842645LC01HU DOCK10 Antibody, FITC conjugated
    Biotin CSB-PA842645LD01HU DOCK10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
  • 基因功能参考文献：
    1. T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms PMID: 21514340
    2. Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells. PMID: 18499258
    3. Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation. PMID: 18835169
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, dendritic spine.
  • 蛋白家族：
    DOCK family
  • 组织特异性：
    Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
  • 数据库链接：

    HGNC: 23479

    OMIM: 611518

    KEGG: hsa:55619

    STRING: 9606.ENSP00000258390

    UniGene: Hs.46578