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DNER Antibody

  • 货号：
    CSB-PA818784NA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of U87 cells with CSB-PA818784NA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DNER Polyclonal antibody
  • Uniprot No.：
    Q8NFT8
  • 基因名：
    DNER
  • 别名：
    bet antibody; Brain EGF repeat-containing transmembrane protein antibody; Bret antibody; Delta and Notch-like epidermal growth factor-related receptor antibody; Delta notch like EGF repeat containing transmembrane antibody; Delta/notch like EGF repeat containing antibody; Delta/notch-like EGF-related receptor antibody; Dner antibody; DNER_HUMAN antibody; PRO299 antibody; Transmembrane protein Bet antibody; UNQ26 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Delta and Notch-like epidermal growth factor-related receptor protein (150-168AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DNER Antibody (CSB-PA818784NA01HU)，的标记方式是Non-conjugated。对于DNER Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA818784NB01HU DNER Antibody, HRP conjugated ELISA
    FITC CSB-PA818784NC01HU DNER Antibody, FITC conjugated
    Biotin CSB-PA818784ND01HU DNER Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
  • 基因功能参考文献：
    1. quantum dot-based immunofluorescent imaging and quantitative analytical system (QD-IIQAS) is an easy and accurate method for assessing DNER and the DNER expression was an independent prognostic factor in prostate cancer. PMID: 29843212
    2. Collectively, our study identified an unexpected transcriptional repression function of the BET bromodomain and a novel mechanism for TAZ upregulation. PMID: 27717711
    3. our findings show that targeting BET proteins for degradation represents an effective therapeutic strategy for Triple-negative breast cancers (TNBC)treatment PMID: 28209615
    4. is not a Notch ligand PMID: 27622512
    5. we review and discuss the structural biology of BET family BDs and their applications in major diseases. PMID: 27240990
    6. DNER rs1861612 C to T change and variant T genotype may contribute to T2DM in a Chinese Han population PMID: 25300688
    7. These studies implicate DNER as a susceptibility gene for T2DM in American Indians. PMID: 24101674
    8. Our data suggest that clathrin-independent endocytosis is critical for the polarized targeting of somatodendritic proteins(DNER). PMID: 20367751
    9. The inhibition of DNER protein resulted in an increase in adipocyte maturation, partly via a reduction of cell proliferation through elevation of CCAAT-Enhancer-Binding Protein-delta expression. PMID: 20070733
    10. expression in developing and mature central nervous system PMID: 11950833

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in brain, spinal cord and adrenal gland.
  • 数据库链接：

    HGNC: 24456

    OMIM: 607299

    KEGG: hsa:92737

    STRING: 9606.ENSP00000345229

    UniGene: Hs.234074