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DNASE2 Antibody

  • 货号：
    CSB-PA007053GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O00115
  • 基因名：
    DNASE2
  • 别名：
    Acid DNase antibody; Deoxyribonuclease 2 alpha antibody; Deoxyribonuclease 2 antibody; Deoxyribonuclease II alpha antibody; Deoxyribonuclease II antibody; Deoxyribonuclease II lysosomal antibody; Deoxyribonuclease-2-alpha antibody; Deoxyribonuclease2 antibody; DeoxyribonucleaseII antibody; DNASE 2 antibody; DNASE 2A antibody; DNase II alpha antibody; DNase II lysosomal antibody; DNASE2 antibody; DNASE2A antibody; DNaseII antibody; DNL 2 antibody; DNL antibody; DNL2 antibody; DNS2A_HUMAN antibody; Lysosomal DNase II antibody; R31240 2 antibody; R31240_2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DNASE2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
  • 基因功能参考文献：
    1. Study identifies biallelic mutations in DNASE2, associated with a loss of DNase II endonuclease activity causing type I interferonopathy in three patients from two unrelated families. PMID: 29259162
    2. 15 nonsynonymous human DNase II SNPs were genotyped in three ethnic groups including 16 different populations using the PCR-restriction fragment length polymorphism technique. PMID: 24242851
    3. study demonstrated the relationship of genotypes/haplotypes with the in vivo DNase II and promoter activities; significant correlations between genotype in each rheumatoid arthritis (RA)-related SNP and enzymatic activity levels were found; alleles associated with RA exhibited a reduction in serum DNase II activity. PMID: 23019102
    4. upregulation of expression during myelomonocytic differentiation of HL-60 and THP-1 cells PMID: 12147225
    5. Sp1 and Sp3 are involved in up-regulation of this enzyme's transcriptoin during cell differentiation of hl-60 cells. PMID: 12694199
    6. the enzyme is a monomeric phospholipase D-family member with a pseudodimeric protein fold PMID: 17192590
    7. The association of SNPs in the 5'-regulatory region of the DNA degrading enzyme DNASE2 with Rheumatoid Arthritis implies a role for this enzyme in the pathogenesis of this autoimmune disease. PMID: 18812394

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    DNase II family
  • 数据库链接：

    HGNC: 2960

    OMIM: 126350

    KEGG: hsa:1777

    STRING: 9606.ENSP00000222219

    UniGene: Hs.118243