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DNAL1 Antibody

  • 货号：
    CSB-PA002222
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MCF7 cells using Dynein LC 1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q4LDG9
  • 基因名：
    DNAL1
  • 别名：
    axonemal antibody; Axonemal dynein light chain 1 antibody; Axonemal dynein light chain antibody; C14orf168 antibody; Chromosome 14 open reading frame 168 antibody; CILD16 antibody; DNAL 1 antibody; dnal1 antibody; DNAL1_HUMAN antibody; Dynein axonemal light chain 1 antibody; Dynein light chain 1 antibody; Dynein light chain 1 axonemal antibody; MGC12435 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Dynein LC 1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency. Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme. Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry.
  • 基因功能参考文献：
    1. DNAL1 and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation. PMID: 22018492
    2. DNAL1 mutation could help to elucidate the interaction between the DNAL1 to dynein heavy chain and to tubulin. PMID: 21496787
    3. identification of the human (DNAL1) ortholog of the Chlamydomonas LC1-gene; protein interaction studies demonstrated binding of DNAL1 and DNAH5; DNAL1 considered a candidate for primary ciliary dyskinesia PMID: 15845866
  • 相关疾病：
    Ciliary dyskinesia, primary, 16 (CILD16)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, cilium axoneme.
  • 蛋白家族：
    Dynein light chain LC1-type family
  • 组织特异性：
    Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis.
  • 数据库链接：

    HGNC: 23247

    OMIM: 610062

    KEGG: hsa:83544

    STRING: 9606.ENSP00000452037

    UniGene: Hs.271270