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DNAJC2 Antibody

  • 货号：
    CSB-PA858715ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA858715ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA858715ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DNAJC2 Polyclonal antibody
  • Uniprot No.：
    Q99543
  • 基因名：
    DNAJC2
  • 别名：
    AU020218 antibody; DnaJ (Hsp40) homolog subfamily C member 2 antibody; DnaJ homolog subfamily C member 2 antibody; Dnajc2 antibody; DNJC2_HUMAN antibody; M phase phosphoprotein 11 antibody; M-phase phosphoprotein 11 antibody; MGC105894 antibody; MIDA1 antibody; MPHOSPH11 antibody; MPP11 antibody; OTTMUSP00000031226 antibody; ZRF1 antibody; Zrf2 antibody; ZUO1 antibody; Zuotin related factor 1 antibody; Zuotin related factor 2 antibody; Zuotin-related factor 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DnaJ homolog subfamily C member 2 protein (1-140AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
  • 基因功能参考文献：
    1. These findings suggest that ZRF1 plays a crucial role in tumor malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer PMID: 29228320
    2. Unexplored functions of ZRF1-mediated remodeling in replication and double strand break repair are discussed. PMID: 27599465
    3. ZRF1 mediates remodeling of this E3 ligase complex directly at the DNA lesion site. PMID: 27091446
    4. The antibody response to ZRF1 was higher in sera of patients with invasive ductal carcinoma than in sera of patients with other histological types of breast tumors. PMID: 27847402
    5. Zrf1 is transcriptional regulator of neural fate downstream of Id1 in embryonic stem cells.During embryonic stem cell differentiation, Id1 levels decrease allowing Zrf1 to activate neural genes. PMID: 25361733
    6. our data reveal that ZRF1 is a key transcriptional regulator in leukemia progression PMID: 24292673
    7. Zrf1 plays an essential role in neural progenitor cell generation and maintenance PMID: 24449271
    8. ZRF1 regulates the INK4-ARF locus during cellular proliferation and senescence, and alterations in ZRF1 may contribute to tumorigenesis. PMID: 22733129
    9. the majority of AML patients elicited a humoral immune response against the tumor antigen MPP11 PMID: 22433847
    10. describe a novel epitope derived from the MPP11 antigen that has been recognized by human CD8+ CTL PMID: 20231810
    11. At the onset of differentiation, ZRF1 specifically displaces polycomb-repressive complex 1 (PRC1) from chromatin and facilitates transcriptional activation PMID: 21179169
    12. concluded that Mpp11, an ortholog of yeast Zuo, is a ribosome-associated J protein; proposed that in metazoans, ribosome-associated Zuo and Mpp11 orthologs recruit cytosolic Hsc70 to short ribosome-bound nascent chains as they exit the ribosome PMID: 15802566
    13. MPP11 is localized to the cytosol and with Hsp70L1, forms the mammalian ribosome-associated complex. PMID: 16002468

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 13192

    OMIM: 605502

    KEGG: hsa:27000

    STRING: 9606.ENSP00000368565

    UniGene: Hs.558476