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DNAJB9 Antibody

  • 货号：
    CSB-PA866205ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA866205ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA866205ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DNAJB9 Polyclonal antibody
  • Uniprot No.：
    Q9UBS3
  • 基因名：
    DNAJB9
  • 别名：
    DKFZP564F1862 antibody; DnaJ (Hsp40) homolog subfamily B member 9 antibody; DnaJ homolog subfamily B member 9 antibody; DNAJB9 antibody; DNJB9_HUMAN antibody; eEndoplasmic reticulum DNA J domain containing protein 4 antibody; Endoplasmic reticulum DnaJ homolog 4 antibody; ER resident protein ERdj4 antibody; ERdj4 antibody; MDG 1 antibody; Mdg-1 antibody; MDG1 antibody; Microvascular endothelial differentiation gene 1 antibody; Microvascular endothelial differentiation gene 1 protein antibody; MST049 antibody; MSTP049 antibody; OTTHUMP00000206840 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DnaJ homolog subfamily B member 9 protein (24-223AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
  • 基因功能参考文献：
    1. Study reports that the endoplasmic reticulum luminal co-chaperone ERdj4/DNAJB9 is a selective IRE1 repressor that promotes a complex between the luminal Hsp70 BiP and the luminal stress-sensing domain of IRE1alpha. PMID: 29198525
    2. these results demonstrate that DNAJB9 is a downstream target of p53 that belongs to the group of negative feedback regulators of p53. PMID: 25146923
    3. ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity. PMID: 18400946
  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 组织特异性：
    Widely expressed. Expressed at highest level in the liver, placenta and kidney.
  • 数据库链接：

    HGNC: 6968

    OMIM: 602634

    KEGG: hsa:4189

    STRING: 9606.ENSP00000249356

    UniGene: Hs.732494