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DNAJB8 Antibody

  • 货号：
    CSB-PA836779LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DNAJB8 antibody at 8µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Mouse brain tissue
      Lane 3: Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA836779LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA836779LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The DNAJB8 antibody is produced by immunizing rabbits with the recombinant human DNAJB8 protein (1-232AA) and then antigen-affinity-purified from rabbit antiserum. It occurs as an unconjugated IgG. It shows reactivity with human and mouse DNAJB8 protein, which plays a role in the suppression of toxic polyglutamine (poly Q) protein aggregation and in vivo tumor initiation. This DNAJB8 antibody has been validated for use in ELISA, WB, and IHC applications.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DNAJB8 Polyclonal antibody
  • Uniprot No.：
    Q8NHS0
  • 基因名：
    DNAJB8
  • 别名：
    DJ6 antibody; DnaJ (Hsp40) homolog; subfamily B; member 8 antibody; DnaJ homolog subfamily B member 8 antibody; Dnajb8 antibody; DNJB8_HUMAN antibody; mDj6 antibody; MGC33884 antibody; OTTHUMP00000216243 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human DnaJ homolog subfamily B member 8 protein (1-232AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DNAJB8 Antibody (CSB-PA836779LA01HU)，的标记方式是Non-conjugated。对于DNAJB8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836779LB01HU DNAJB8 Antibody, HRP conjugated ELISA
    FITC CSB-PA836779LC01HU DNAJB8 Antibody, FITC conjugated
    Biotin CSB-PA836779LD01HU DNAJB8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
  • 基因功能参考文献：
    1. DNAJB8 is a central and versatile player in the protein aggregation and degradation system.DNAJB8 protein keeps Parkin C289G mutant protein in a soluble, degradation-competent form. PMID: 27713507
    2. Results show that DNAJB8 expression is induced by heat shock stress which increases side population cells and cancer stem-like cells. PMID: 29316077
    3. Taken together, the results indicate that DNAJB8 is expressed and has role in CRC CSC/CIC and that DNAJB8 is a novel target of CRC CSC/CIC-targeting immunotherapy. PMID: 24450541
    4. The mechanism of DNAJB6 and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract. PMID: 23612975
    5. Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma PMID: 22552285
    6. DNAJB6b and DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins. PMID: 20159555

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  • 数据库链接：

    HGNC: 23699

    OMIM: 611337

    KEGG: hsa:165721

    STRING: 9606.ENSP00000316053

    UniGene: Hs.518241