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DMXL2 Antibody

  • 货号：
    CSB-PA819469LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA819469LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA819469LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DMXL2 Polyclonal antibody
  • Uniprot No.：
    Q8TDJ6
  • 基因名：
    DMXL2
  • 别名：
    DmX-like protein 2 antibody; Dmxl2 antibody; DMXL2_HUMAN antibody; KIAA0856 antibody; Rabconnectin-3 antibody; RC3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DmX-like protein 2 protein (2471-2657AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DMXL2 Antibody (CSB-PA819469LA01HU)，的标记方式是Non-conjugated。对于DMXL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA819469LB01HU DMXL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA819469LC01HU DMXL2 Antibody, FITC conjugated
    Biotin CSB-PA819469LD01HU DMXL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes.
  • 基因功能参考文献：
    1. Data indicated that the p.Arg2417His variant in DMXL2 is associated with dominant, nonsyndromic hearing loss and suggested an important role of DMXL2 in inner ear function. PMID: 27657680
    2. s demonstrate that DMXL2 is a transmembrane protein with a potential extra-cellular domain. These findings identify DMXL2 as a novel, functional biomarker for ERalpha positive breast cancer. PMID: 26093085
    3. Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice. PMID: 25248098
    4. an important role for Rabconnectin-3 and V-ATPase activity in the Notch signaling pathway in mammalian cells. PMID: 20810660
  • 相关疾病：
    Polyendocrine-polyneuropathy syndrome (PEPNS); Deafness, autosomal dominant, 71 (DFNA71)
  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
  • 数据库链接：

    HGNC: 2938

    OMIM: 612186

    KEGG: hsa:23312

    STRING: 9606.ENSP00000441858

    UniGene: Hs.511386