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DLX4 Antibody

  • 货号：
    CSB-PA002156
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using Dlx-4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q92988
  • 基因名：
    DLX4
  • 别名：
    Beta protein 1 antibody; BP1 antibody; Distal less homeo box 7 antibody; Distal less homeo box 9 antibody; distal-less homeobox 4 antibody; DLX4 antibody; DLX4_HUMAN antibody; DLX7 antibody; DLX8 antibody; DLX9 antibody; Homeobox protein DLX-4 antibody; Homeobox protein DLX-7 antibody; Homeobox protein DLX-8 antibody; Homeobox protein DLX4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Dlx-4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.
  • 基因功能参考文献：
    1. Beta protein 1 (BP1) binds to and regulates estrogen receptor. PMID: 27449292
    2. study indicated that DLX4 hypermethylation was a frequent event and acted as an independent prognostic biomarker in de novo myelodysplastic syndrome patients PMID: 26485746
    3. Our study reveals that BP1 overexpression serves as an independent risk factor in de novo AML patients. PMID: 26325005
    4. Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta and NF-kappaB signaling. PMID: 26208636
    5. DLX4 induces CD44 by stimulating IL-1beta-mediated NF-kappaB activity, thereby promoting peritoneal metastasis of ovarian cancer PMID: 26067154
    6. This first finding of a DLX4 mutation in a family with Cleft lip and/or palate establishes DLX4 as a potential cause of human clefts PMID: 25954033
    7. DLX4 promotes ovarian tumor angiogenesis in part by stimulating iNOS expression. PMID: 25924901
    8. Aberrant DNA methylation of the DLX4 and SIM1 genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions. PMID: 25614457
    9. indicate that gains of DLX4 and ERBB2 occur in South African breast cancer patients irrespectively of their race and factors known to influence prognosis PMID: 26524685
    10. a DLX4 overexpression vector lacking the 3'UTR was shown to abolish miR-122-induced inhibition of proliferation in the HCC cell line Hep3B. PMID: 25823567
    11. DLX4 can functionally replace c-MYC. PMID: 25471527
    12. Methylated DLX4 is a potential biomarker that predicts poor prognosis after curative resection of pathologic stage I Non-Small Cell Lung Cancer. PMID: 25825198
    13. DLX4 increased copy number was observed in 21.6% of the primary breast tumors and 24.3% of the sentinel lymph node metastasis PMID: 24947980
    14. The results suggest that high expression of DLX4 predicts hepatocellular carcinoma prognosis. PMID: 24824934
    15. All trans retinoic acid can inhibit the proliferation and the expression of BP1 in breast cancer cells. PMID: 23158431
    16. DLX4 induces cancer cells to undergo epithelial to mesenchymal transition through TWIST, enhancing tumor migration, invasion and metastasis. PMID: 23091415
    17. findings suggest that decreased expression of homeobox protein DLX-4 leads to the pathogenesis of preeclampsia by inhibiting epithelial-mesenchymal transition in trophoblasts PMID: 21602546
    18. The ability of DLX4 to counteract key transcriptional control mechanisms of the TGF-beta cytostatic program could explain, in part, the resistance of tumors to the antiproliferative effect of TGF-beta. PMID: 21297662
    19. BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. PMID: 11909945
    20. involvement of BP1 in the mechanism of the negative regulation of beta-globin transcription. PMID: 15308321
    21. BP1 can negatively modulate adult beta-globin gene expression and definitive erythroid cell differentiation, and suggest that BP1 could play a role in thalassemia. PMID: 17003054
    22. Increased expression of homeobox gene DLX4 may be a contributing factor to the developmental abnormalities seen in the FGR-affected placentae. PMID: 17062780
    23. we were able to show that enforced expression of the DLX4 homeobox gene markedly inhibited in vitro motility and invasion as well as in vivo metastasis via both hematogenous and lymphogenous routes. PMID: 17260014
    24. results support the notion that BP1 might contribute to breast neoplastic transformation or tumor progression and suggest for the first time that BP1 mRNA level has potential as a prognostic predictor for breast cancer PMID: 17999690
    25. BP1 may regulate bcl-2 and c-myc expression PMID: 18026954
    26. BP1 may be part of a pathway contributing to non-small cell lung cancer (NSCLC) development and/or progression and mRNA level could be a novel prognostic marker for NSCLC. PMID: 18420035
    27. BP1 is an important upstream factor in the carcinogenic pathway of prostate cancer and that the expression of BP1 may reflect or directly contribute to tumor progression and/or invasion. PMID: 18931648
    28. Other mechanisms in addition to gene amplification play a role in BP1 protein expression om breast camcer/ PMID: 18992636
    29. High BP1 expression is associated with inflammatory breast cancer and tumor aggressiveness PMID: 19242057

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  • 相关疾病：
    Non-syndromic orofacial cleft 15 (OFC15)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Distal-less homeobox family
  • 组织特异性：
    Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.
  • 数据库链接：

    HGNC: 2917

    OMIM: 601911

    KEGG: hsa:1748

    STRING: 9606.ENSP00000240306

    UniGene: Hs.591167