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DLG5 Antibody

  • 货号：
    CSB-PA006939GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TDM6
  • 基因名：
    DLG5
  • 别名：
    Discs large homolog 5 (Drosophila) antibody; Discs large homolog 5 antibody; Discs large protein LP DLG antibody; Discs large protein P dlg antibody; Discs large protein P-dlg antibody; Disks large homolog 5 antibody; DLG 5 antibody; DLG5 antibody; DLG5_HUMAN antibody; KIAA0583 antibody; Large type of P DLG antibody; LP DLG antibody; P DLG5 antibody; PDLG antibody; Placenta and prostate DLG antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human DLG5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
  • 基因功能参考文献：
    1. Loss of DLG5 expression promoted breast cancer progression by inactivating the Hippo signaling pathway and increasing nuclear YAP. PMID: 28169360
    2. both polymorphisms of DLG5 are correlated with inflammatory bowel disease susceptibility in an ethnic-specific manner. PMID: 27633114
    3. Low expression of DLG5 is associated with Crohn's disease. PMID: 27760079
    4. Data found that Dlg5 expression was significantly lower in human hepatocellular carcinoma (HCC) tissues and indicate that Dlg5 acts as a novel regulator of invadopodium-associated invasion via Girdin and by interfering with the interaction between Girdin and Tks5, which might be important for Tks5 phosphorylation in HCC cells. PMID: 28390157
    5. G113A variant may be significantly associated with Crohn's disease risk in children and colonic involvement (Meta-Analysis) PMID: 27338058
    6. DLG5 inhibits the association between MST1/2 and large tumor suppressor homologs 1/2 (LATS1/2), uses its scaffolding function to link MST1/2 with MARK3, and inhibits MST1/2 kinase activity PMID: 28087714
    7. Pooled data indicated no significant association between DLG5113G/A gene polymorphism and the development of Crohn's disease PMID: 27309475
    8. These data suggest that inhibition of Dlg5 by DNA hypermethylation contributes to provoke invasive phenotypes in bladder tumor. PMID: 25478998
    9. Findings demonstrate that Dlg5 interacts with and inhibits the activity of Girdin, thereby suppressing the migration of prostate cancer cells. PMID: 24662825
    10. DLG5 plays a role in cell migration, cell adhesion, precursor cell division, cell proliferation, epithelial cell polarity maintenance, and transmission of extracellular signals to the membrane and cytoskeleton. PMID: 24910533
    11. Overexpression of Dlg5 enhances the degradation of TGFBRI. PMID: 23624079
    12. Polymorphisms in the DLG5 gene were found to be associated with Crohn's disease patients in Malaysia. PMID: 22118696
    13. Examined the genetic association of DLG5 SNP P1371Q with inflammatory bowel disease and its interaction with R30Q in disease susceptibility. P1371Q is complementary to R30Q, with R30Q exhibiting a dominant effect in IBD susceptibility. PMID: 22065243
    14. Increased expression of discs large homolog 5 gene is associated with ulcerative colitis. PMID: 21674725
    15. In the studied population, DLG5 R30Q was associated with all forms of IBD. An elevated presence of the R30Q variant was observed in all members of a familial IBD registry PMID: 20037206
    16. findings suggest that lp-dlg/KIAA0583 is a novel scaffolding protein that can link the vinexin-vinculin complex and beta-catenin at sites of cell-cell contact PMID: 12657639
    17. Genetic variation in DLG5 is associated with inflammatory bowel disease PMID: 15107852
    18. Collaboration of RAB6KIFL and DLG5 is likely to be involved in pancreatic cancer. PMID: 15665285
    19. DLG5 constitutes a true inflammatory bowel diseases risk factor of modest effect PMID: 15841097
    20. there are significant population allele frequency differences at the DLG5 gene [letter] PMID: 16391570
    21. The G113A polymorphism of the DLG5 gene was completely absent in Greek Crohn disease cases as well as the Greek healthy population PMID: 16437728
    22. R30Q variant constitutes a susceptibility factor for Crohn disease (CD) in men. PMID: 16446977
    23. The results indicate a role for DLG5 variants in inflammatory bowel disease (IBD) susceptibility. PMID: 16450402
    24. The initial report of DLG5 as a novel inflammatory bowel disease (IBD) susceptibility gene sparked a multitude of studies concerning its role in the aetiology of Crohn disease and IBD. PMID: 16773680
    25. The R30Q variant in the DLG5 gene does not appear to be associated with an overall increase in the risk of disease in a British IBD cohort PMID: 16944184
    26. DLG5 has a gender-specific role in the susceptibility of pediatric CD. Significant negative association found between DLG5 R30Q and CD in female children suggests DLG5 may have a protective effect in CD susceptibility for female children. PMID: 17156146
    27. DLG5 gene missense mutation is associated with increased susceptibility to inflammatory bowel diseases in children. PMID: 17307543
    28. polymorphism exerts a weak influence on Crohn's disease phenotype PMID: 17451203
    29. the DLG5 haplotype A is associated with reduced risk of inflammatory bowel disease in the New Zealand Caucasian population PMID: 17455201
    30. polymorphisms 3020insC in CARD15 and SNP rs2165047 in DLG5 may have a role in pediatric-onset Crohn's disease PMID: 17476680
    31. DLG5 30Q is associated with a small reduction in risk of Crohn disease in women in a Caucasian cohort. PMID: 17693570
    32. Results provide evidence that the scaffolding protein DLG5 belongs to the CARD protein family. PMID: 18335190
    33. findings show that the inflammatory bowel disease-susceptibility gene DLG5 is also associated with gluten-sensitive enteropathy PMID: 18559397

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  • 亚细胞定位：
    Cell junction. Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cytoplasm, cytoskeleton, cilium basal body. Note=Localized at sites of cell-cell contact.
  • 蛋白家族：
    MAGUK family
  • 组织特异性：
    Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, hea
  • 数据库链接：

    HGNC: 2904

    OMIM: 604090

    KEGG: hsa:9231

    STRING: 9606.ENSP00000361467

    UniGene: Hs.652690