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DKKL1 Antibody

  • 货号：
    CSB-PA892450LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892450LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DKKL1 Polyclonal antibody
  • Uniprot No.：
    Q9UK85
  • 基因名：
    DKKL1
  • 别名：
    Cancer/testis antigen 34 antibody; CT34 antibody; dickkopf like 1 antibody; Dickkopf-like protein 1 antibody; DKKL1 antibody; DKKL1_HUMAN antibody; Protein soggy-1 antibody; SGY antibody; SGY-1 antibody; SGY1 antibody; soggy 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dickkopf-like protein 1 protein (31-242AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DKKL1 Antibody (CSB-PA892450LA01HU)，的标记方式是Non-conjugated。对于DKKL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892450LB01HU DKKL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA892450LC01HU DKKL1 Antibody, FITC conjugated
    Biotin CSB-PA892450LD01HU DKKL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
  • 基因功能参考文献：
    1. DKKL was overexpressed in colorectal cancer tissue compared with healthy colon. DKKL expression positively correlated with colorectal cancer progression. PMID: 27635108
    2. previously unreported alternative splicing patterns in the genes ZNF419 and DKKL1 PMID: 27826023
    3. Findings suggest that Dkk-3 plays a role in the regulation of cell interactions during retinoic acid-induced neuronal differentiation; effect on apoptosis was also observed upon expression of the related protein Dkkl-1 PMID: 24909558
    4. DKKL1/Dkkl1 may play an important role in testicular development and spermatogenesis and may be an important factor in male infertility. PMID: 22817830
  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.
  • 组织特异性：
    More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.
  • 数据库链接：

    HGNC: 16528

    OMIM: 605418

    KEGG: hsa:27120

    STRING: 9606.ENSP00000221498

    UniGene: Hs.515855