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DIXDC1 Antibody

  • 货号：
    CSB-PA621878LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA621878LA01HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DIXDC1 Polyclonal antibody
  • Uniprot No.：
    Q155Q3
  • 基因名：
    DIXDC1
  • 别名：
    CCD1 antibody; Ccd1Aalpha1L antibody; Ccd1Abeta1L antibody; Ccd1BalphaL antibody; Ccd1BbetaL antibody; Ccd1CL antibody; Coiled coil DIX1 antibody; Coiled coil protein DIX1 antibody; Coiled-coil protein DIX1 antibody; Coiled-coil-DIX1 antibody; DIX domain containing 1 antibody; DIX domain containing protein 1 antibody; DIX domain-containing protein 1 antibody; DIXC1_HUMAN antibody; DIXDC1 antibody; Dixin antibody; KIAA1735 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dixin protein (70-333AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DIXDC1 Antibody (CSB-PA621878LA01HU)，的标记方式是Non-conjugated。对于DIXDC1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA621878LB01HU DIXDC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA621878LC01HU DIXDC1 Antibody, FITC conjugated
    Biotin CSB-PA621878LD01HU DIXDC1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
  • 基因功能参考文献：
    1. DIXDC1 silencing inhibited cell proliferation, invasion, and Wnt signaling in retinoblastoma cell lines. DIXDC1 was identified as a target gene of miR-186 PMID: 29264763
    2. MiR-539 inhibits glioma cell proliferation and invasion by targeting DIXDC1. PMID: 28704799
    3. DIXDC1 might participate in the development of glioma. PMID: 27817168
    4. Overexpression of DIXDC1 correlates with enhanced cell growth and poor prognosis in human pancreatic ductal adenocarcinoma. PMID: 27498060
    5. found that DIXDC1 could promote cell proliferation via modulating cell cycle progression and PI3K/AKT signaling pathway in NHLs PMID: 27701018
    6. Taken together, our results suggest that DIXDC1 plays an important role in regulating prostate cancer cell proliferation and invasion. Targeting DIXDC1 by miR-1271 may be a promising therapeutic strategy for prostate cancer. PMID: 28153722
    7. Downregulated expression of DIXDC1 is associated with hepatocellular carcinoma. PMID: 27468723
    8. DIXDC1 was overexpressed in gastric cancer and correlated with poor prognosis. PMID: 25648220
    9. DIXDC1 is associated with stage and prognosis in non-small cell lung cancer, and may promote invasion and migration through PI3K-AKT/AP-1-dependent activation of metalloproteinases PMID: 23813858
    10. DIXDC1 depletion results in upregulation of Snail1 in a FAK-dependent manner, leading to increased cell invasion. MARK1 phosphorylation of DIXDC1 is required for its localization to focal adhesions and ability to suppress metastasis in mice. PMID: 25042806
    11. Transgenic DIXDC1 might contribute to pathophysiology underlying abnormal behaviors in schizophrenia and other major psychiatric disorders in mice. PMID: 22832659
    12. a molecular mechanism for Ccd1-mediated Wnt activation in that Ccd1 converts latent polymeric Dvl to a biologically active oligomer(s). PMID: 21189423
    13. This study reveal that Dixdc1 integrates DISC1 into Wnt-GSK3beta/beta-catenin-dependent and -independent signaling pathways during cortical development and further delineate how DISC1 contributes to neuropsychiatric disorders. PMID: 20624590
    14. Wnt/beta-catenin pathway activation might upregulate DIXDC1 through a post-translational mechanism by inhibiting the ubiquitin-mediated degradation of the DIXDC1 protein. PMID: 20085589
    15. KIAA1735 maps to human chromosome 11q23.1 and encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain PMID: 12792787
    16. Ccd1 inhibits Axin-mediated JNK activation by simultaneously adopting two distinct mechanisms, one through conformational changes that disallow MEKK1 binding and the other via direct sequestration of MEKK4. PMID: 15262978
    17. Thus, our data provide the first evidence that l-DIXDC1 may act as a novel branching component in the Wnt signaling pathway targeting both beta-catenin-TCF complex for gene expression and cytoskeleton for regulating dynamics of actin filaments. PMID: 16814745
    18. DIXDC1 might play an important role during neurogenesis, overexpression of DIXDC1 in embryonic carcinoma P19 cells promoted neuronal differentiation, and inhibited gliogenesis induced by retinoic acid. PMID: 18629627
    19. The GFP-tag fused DIXDC1 exogenously expressed co-localize with gamma-tubulin both at interphase and mitotic phase in the centrosomes. PMID: 19375513
    20. over-expression of DIXDC1 might target p21 and cyclin D1 to promote colon cancer cell proliferation and tumorigenesis at least partially through activation of the PI3K/Akt pathway. PMID: 19572978
    21. MTHDIX (KIAA1735) protein consists of Myosine-tail homologous (MTH) domain and C-terminal DIX domain. PMID: 12792787

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    DIXDC1 family
  • 组织特异性：
    Ubiquitously expressed with higher expression in cardiac and skeletal muscles.
  • 数据库链接：

    HGNC: 23695

    OMIM: 610493

    KEGG: hsa:85458

    STRING: 9606.ENSP00000394352

    UniGene: Hs.655626