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DIS3 Antibody

  • 货号：
    CSB-PA006911GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2L1
  • 基因名：
  • 别名：
    2810028N01Rik antibody; bA555G22 antibody; Dis3 antibody; DIS3 homolog; exosome endoribonuclease and 3'-5' exoribonuclease antibody; DIS3 mitotic control homolog (S. cerevisiae) antibody; DIS3 mitotic control homolog antibody; DIS3 mitotic control; S. cerevisiae; homolog of antibody; dis3p antibody; EXOSC11 antibody; Exosome complex exonuclease RRP44 antibody; exosome component 11 antibody; KIAA1008 antibody; Mitotic control protein dis3 homolog antibody; Protein DIS3 homolog antibody; Ribosomal RNA processing protein 44 antibody; Ribosomal RNA processing protein 44; S. cerevisiae; homolog of antibody; Ribosomal RNA-processing protein 44 antibody; RP11-342J4.3 antibody; RRP44 antibody; RRP44_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DIS3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
  • 基因功能参考文献：
    1. The 3.8 A resolution cryo-EM structure of the core complex bound to a single-stranded RNA reveals that the RNA channel path is formed by two distinct features of the hDIS3 exoribonuclease: an open conformation and a domain organization more similar to bacterial RNase II than to yeast Rrp44. PMID: 30047866
    2. Results from a study on gene variability markers in early-stage human embryos shows that DIS3 is a putative variability marker for the 3-day, 8-cell embryo stage, identified by mixture models as well as standard ANOVA. PMID: 26288249
    3. s have identified a putative functional indel variant at chr13q22.1 that associates with decreased DIS3 expression in carriers of pancreatic cancer risk-increasing alleles, and could therefore affect nuclear RNA processing and/or decay. PMID: 28172817
    4. Data indicate the pathological relevance of exosome component 11 protein (DIS3) mutations in plasma cell dyscrasias and suggest that DIS3 may represent a potential tumor suppressor gene in such disorders. PMID: 26305418
    5. structure and function of DIS3 PMID: 26193331
    6. The study establishes that the ribonuclease DIS3, targeting LIN28B, sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation. PMID: 25925570
    7. seven novel somatic DIS3 single nucleotide variants (SNVs) and defined three hot spot mutations within the RNB domain. PMID: 25521164
    8. Overexpression of DIS3 and LRCH1 associated with adenoma to carcinoma progression is linked to the colorectal cancer specific gain of 13q. PMID: 24478024
    9. Multiple myeloma-associated hDIS3 mutations interfere with hDIS3 exonucleolytic activity. PMID: 24150935
    10. Data show that hDIS3 and hDIS3L are active exonucleases, but only hDIS3 has retained endonucleolytic activity, and suggest that three different ribonucleases can serve as catalytic subunits for the exosome in human cells. PMID: 20531386
    11. S. cerevisiae Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing, S. cerevisiae Dis3p was found to be localized in the nucleolus. PMID: 9562621
    12. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. There appears to be no interaction between human dis3 and other exosome subunits, however. PMID: 12419256
    13. Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing. Similar to S. cerevisiae Dis3p, human Dis3p enhanced RCC1-stimulated nucleotide release from Ran, in a dose-dependent manner, and bound to GTP- or GDP-Ran. PMID: 9562621

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  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
  • 蛋白家族：
    RNR ribonuclease family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 20604

    OMIM: 607533

    KEGG: hsa:22894

    STRING: 9606.ENSP00000366997

    UniGene: Hs.744104