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DIMT1 Antibody

  • 货号：
    CSB-PA892161LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DIMT1 antibody at 2μg/ml + Mouse thymus tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 35 kDa
      Observed band size: 35 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA892161LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA892161LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DIMT1 Polyclonal antibody
  • Uniprot No.：
    Q9UNQ2
  • 基因名：
    DIMT1
  • 别名：
    18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase antibody; 18S rRNA dimethylase antibody; DIM1 antibody; DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) antibody; DIM1 dimethyladenosine transferase 1 homolog antibody; DIM1 dimethyladenosine transferase 1 like antibody; DIM1 dimethyladenosine transferase 1-like antibody; Dimethyladenosine transferase antibody; DIMT1 antibody; DIMT1_HUMAN antibody; DIMT1L antibody; HSA9761 antibody; HUSSY5 antibody; N''-adenosyl(rRNA) dimethyltransferase antibody; Probable 18S rRNA (adenine(1779) N(6)/adenine(1780) N(6)) dimethyltransferase antibody; Probable 18S rRNA dimethylase antibody; Probable dimethyladenosine transferase antibody; Probable S adenosylmethionine 6 N',N' adenosyl(rRNA) dimethyltransferase antibody; S adenosylmethionine 6 N',N' adenosyl(rRNA) dimethyltransferase antibody; S-adenosylmethionine-6-N'' antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Probable dimethyladenosine transferase protein (1-313AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DIMT1 Antibody (CSB-PA892161LA01HU)，的标记方式是Non-conjugated。对于DIMT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892161LB01HU DIMT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA892161LC01HU DIMT1 Antibody, FITC conjugated
    Biotin CSB-PA892161LD01HU DIMT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.
  • 基因功能参考文献：
    1. DIMT1 is overexpressed in gastric carcinoma and is significantly correlated with poor prognosis. PMID: 28601661
    2. Studies show that miroRNA miR-210 acts as a tumor suppressor in hypoxic conditions by downregulating the 18S rRNA base methyltransferase (DIMT1)-interferon regulatory factor 4 (IRF4) axis. PMID: 28164410
    3. DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA. Ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity. PMID: 25851604
    4. Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection by activating STMN1 and DIMT1. PMID: 25187177
  • 亚细胞定位：
    Nucleus, nucleoplasm. Nucleus, nucleolus.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family
  • 数据库链接：

    HGNC: 30217

    OMIM: 612499

    KEGG: hsa:27292

    STRING: 9606.ENSP00000199320

    UniGene: Hs.731665